Race is a risk factor for calcinosis in patients with JDM – early results from the CARRAnet registry study
Bibliographic record
Abstract
Children with juvenile dermatomyositis (JDM) in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) registry study were included in this analysis. Race and ethnicity were self-reported. Subjects with current or past calcinosis were identified, and bi-variable associations between clinical variables and calcinosis were evaluated by Chi-square test, Fisher exact test, two-sample t-test, or Wilcoxon Rank Sum test as appropriate. A multivariable stepwise logistic regression model was run that included variables that were significantly associated in the bi-variable analysis, defined by P <0.1. All statistical analyses were conducted using JMP Stats version 8.0 (SAS Institute, Cary, NC). Prior to December 28, 2010, 102 subjects meeting modified Bohan and Peter criteria for JDM were enrolled from 23 U.S. sites. Fifteen subjects were excluded due to lack of data regarding calcinosis or race. Ten of the remaining 87 patients had a history of calcinosis. Potential predictors of calcinosis identified a priori included race, ethnicity, sex, ANA status, age, age of onset, duration of disease, and time to rheumatologic care. Bi-variable analyses revealed a significant association between calcinosis and African American (AA) race ( P =0.029), disease duration ( P =0.005), absence of antinuclear antibodies ( P =0.024), and male gender ( P =0.037) (Table 1 ). Analyzing these four variables in a multiple stepwise logistic regression model revealed that AA ancestry was the most significant predictor of calcinosis (OR [95% CI] 5.8 [1.3, 24.8] P =0.019). When demographic variables and outcome assessments were compared between AA patients and non-AA patients, only CHAQ scores were statistically significantly different in AA patients (mean (±SD), 0.54 (±0.51) vs. 0.29 (±0.52) in non-AA patients [ P = 0.033]). Children with JDM of African American ancestry have increased odds of developing calcinosis, even after controlling for duration of disease and time to rheumatologic care. Male gender, negative ANA status, and disease duration were associated with calcinosis in bi-variable analysis, however, these variables were limited by incomplete data capture, which may have affected the results of the multi-variable regression model. Analysis of a larger more complete cohort is needed to confirm these observations.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".