Eruption associated with amoxicillin in a patient with infectious mononucleosis
Notice bibliographique
Résumé
A 9‐year‐old boy presented with a history of fever, malaise, and sore throat for 1 day. He was seen by his family physician who diagnosed tonsillitis. The past medical history was unremarkable. There was no previous history of allergy to medications. After a throat swab had been taken and sent for bacterial culture, the patient was started on amoxicillin, 250 mg three times daily. Two days later, the child developed an extensive pruritic eruption over the body. We were consulted at this point. On examination, the child was afebrile. His pulse rate was 74/min and his blood pressure was 90/60 mmHg. An erythematous, maculopapular eruption was noted on the face, neck, trunk, buttocks, and extremities ( Fig. 1 ). The palms and soles were also involved, but to a lesser extent. The pharynx and tonsils were erythematous. Yellowish exudates were seen in the tonsillar area. There were shotty lymph nodes in the cervical area. The spleen and liver were not palpable. The rest of the physical examination was normal. An erythematous maculopapular eruption on the extremities image A provisional diagnosis of infectious mononucleosis was made. In the meantime, the throat swab culture came back as negative. Amoxicillin therapy was discontinued. Hydroxyzine hydrochloride, 10 mg four times daily as required, was given to relieve the itchiness. Laboratory investigations showed a hemoglobin of 125 g/L, white blood cell count of 12 × 109/L with 75% lymphocytes, 23% neutrophils, 5% monocytes, and 2% eosinophils, and a platelet count of 200 × 109/L. Many atypical lymphocytes were seen in the peripheral smear. Monospot test was positive, confirming the diagnosis of infectious mononucleosis. The child was reassessed 7 days later. By then, the pruritus had subsided and the eruption had cleared without desquamation. The pharynx and tonsils looked normal and there was no cervical lymphadenopathy. The child was seen by his family physician 5 months later because of a left‐sided earache. He was diagnosed with left otitis media and was treated with amoxicillin, 250 mg three times daily for 7 days. No skin eruption was noted with the use of amoxicillin on this occasion.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,001 |
| Méta-épidémiologie (sens large) | 0,001 | 0,001 |
| Bibliométrie | 0,002 | 0,001 |
| Études des sciences et des technologies | 0,002 | 0,001 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,000 | 0,001 |
| Intégrité de la recherche | 0,003 | 0,002 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,003 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».