OC004—Fetal Exposure To Nonsteroidal Antiinflammatory Drugs (Nsaid) And Spontaneous Abortions
Notice bibliographique
Résumé
IntroductionSpontaneous abortions are the most common complication of pregnancy and nonsteroidal anti-inflammatory drugs (NSAID) are among the most widely used groups of drugs during the first trimester of pregnancy. Published data are inconsistent regarding the risk for spontaneous abortions after exposure to NSAID.Patients (or Materials) and MethodsA population-based retrospective cohort study was conducted including all women who conceived between January 2003 and December 2009 and admitted for birth or diagnosed with spontaneous abortion at Soroka Medical Center, Clalit Health Services, Israel. A computerized database of medication dispension was linked with 2 computerized databases containing information on births and spontaneous abortions. Time-varying COX regression models were constructed adjusting for mother’s age, diabetes mellitus, hypothyroidism, hypercoagulable or inflammatory conditions, history of recurrent miscarriages, presence of intrauterine contraceptive device, ethnicity, and self-reporting tobacco use during pregnancy and the year of pregnancy.ResultsThere were 65,457 women who conceived during the study period and admitted at SMC: 58,949 (90.1%) for birth and 6508 (9.9%) for spontaneous abortion. A total of 4495 (6.9%) pregnant women were exposed to NSAID during the study period. Exposure to NSAID was not an independent risk factor for spontaneous abortion as groups (adjusted hazard ratio [HR], 1.08; 95% confidence interval [CI], 0.97–1.20 and adjusted HR, 1.67; 95% CI 0.95–2.95 for nonselective and selective COX2 inhibitors, respectively) or as specific drugs. Additionally, no dose response effect was found.ConclusionIn this large population-based retrospective cohort study, no increased risk for spontaneous abortions was found following exposure to NSAID Table.TableThe unadjusted and adjusted risk (hazard ratios and 95% CI) for spontaneous abortion following exposure to NSAID: results from time-varying multivariate Cox regression models.Exposure to:Spontaneous Abortions Hazard Ratio (95% CI)UnadjustedAdjusted*Nonselective COX inhibitors1.13 (1.01–1.25)1.08 (0.97–1.20)Ibuprofen1.13 (0.98–1.30)1.05 (0.92–1.21)Diclofenac1.21 (0.98–1.48)1.19 (0.97–1.47)Indomethacin3.54 (2.20–5.71)3.33 (2.06–5.36)Naproxen1.87 (0.66–1.17)0.88 (0.66–1.18)Etodolac1.26 (0.88 –1.80)0.14 (0.8–1.64)COX2 selective inhibitors1.97 (1.12–3.47)1.67 (0.95–2.95) Open table in a new tab Disclosure of InterestNone declared. IntroductionSpontaneous abortions are the most common complication of pregnancy and nonsteroidal anti-inflammatory drugs (NSAID) are among the most widely used groups of drugs during the first trimester of pregnancy. Published data are inconsistent regarding the risk for spontaneous abortions after exposure to NSAID.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».