OC004—Fetal Exposure To Nonsteroidal Antiinflammatory Drugs (Nsaid) And Spontaneous Abortions
Bibliographic record
Abstract
IntroductionSpontaneous abortions are the most common complication of pregnancy and nonsteroidal anti-inflammatory drugs (NSAID) are among the most widely used groups of drugs during the first trimester of pregnancy. Published data are inconsistent regarding the risk for spontaneous abortions after exposure to NSAID.Patients (or Materials) and MethodsA population-based retrospective cohort study was conducted including all women who conceived between January 2003 and December 2009 and admitted for birth or diagnosed with spontaneous abortion at Soroka Medical Center, Clalit Health Services, Israel. A computerized database of medication dispension was linked with 2 computerized databases containing information on births and spontaneous abortions. Time-varying COX regression models were constructed adjusting for mother’s age, diabetes mellitus, hypothyroidism, hypercoagulable or inflammatory conditions, history of recurrent miscarriages, presence of intrauterine contraceptive device, ethnicity, and self-reporting tobacco use during pregnancy and the year of pregnancy.ResultsThere were 65,457 women who conceived during the study period and admitted at SMC: 58,949 (90.1%) for birth and 6508 (9.9%) for spontaneous abortion. A total of 4495 (6.9%) pregnant women were exposed to NSAID during the study period. Exposure to NSAID was not an independent risk factor for spontaneous abortion as groups (adjusted hazard ratio [HR], 1.08; 95% confidence interval [CI], 0.97–1.20 and adjusted HR, 1.67; 95% CI 0.95–2.95 for nonselective and selective COX2 inhibitors, respectively) or as specific drugs. Additionally, no dose response effect was found.ConclusionIn this large population-based retrospective cohort study, no increased risk for spontaneous abortions was found following exposure to NSAID Table.TableThe unadjusted and adjusted risk (hazard ratios and 95% CI) for spontaneous abortion following exposure to NSAID: results from time-varying multivariate Cox regression models.Exposure to:Spontaneous Abortions Hazard Ratio (95% CI)UnadjustedAdjusted*Nonselective COX inhibitors1.13 (1.01–1.25)1.08 (0.97–1.20)Ibuprofen1.13 (0.98–1.30)1.05 (0.92–1.21)Diclofenac1.21 (0.98–1.48)1.19 (0.97–1.47)Indomethacin3.54 (2.20–5.71)3.33 (2.06–5.36)Naproxen1.87 (0.66–1.17)0.88 (0.66–1.18)Etodolac1.26 (0.88 –1.80)0.14 (0.8–1.64)COX2 selective inhibitors1.97 (1.12–3.47)1.67 (0.95–2.95) Open table in a new tab Disclosure of InterestNone declared. IntroductionSpontaneous abortions are the most common complication of pregnancy and nonsteroidal anti-inflammatory drugs (NSAID) are among the most widely used groups of drugs during the first trimester of pregnancy. Published data are inconsistent regarding the risk for spontaneous abortions after exposure to NSAID.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".