Infant gut microbiota and the development of wheeze in early childhood
Notice bibliographique
Résumé
Commensal gut microbes play an important role in human development and lifelong health. There is increasing evidence that disruption of the infant gut microbiota may be linked to the development of childhood allergy and asthma-related outcomes, including wheezing. Our objective was to investigate the association of infant gut microbiota diversity and composition with development of wheeze in early childhood. The study population included 160 infants enrolled at the Winnipeg site of the Canadian Healthy Infant Longitudinal Development Study (CHILD) population-based birth cohort. Standardized questionnaires were completed by mothers at 3, 6 and 12 months after birth, and reported on breastfeeding and occurrence of infant wheezing. Wheezing (defined as a whistling sound in the chest lasting more than 15 minutes and occurring with or without a cold) was classified according to the number of episodes in the first year of life: 0, 1, 2 or ≥3. Mode of delivery and use of antibiotics were documented from hospital and medical records. Fecal samples were collected at one year of age and microbiota composition (relative abundance of select taxa) was characterized by high-throughput Illumina sequencing of the 16S rRNA gene. Biodiversity was evaluated using the Chao1 richness estimator and the Shannon & Simpson diversity indices. In the first year of life, any wheezing as defined above was reported for 36/160 infants (22.5%). Sixteen infants (10.0%) wheezed on more than one occasion, and 12 infants (7.5%) experienced 3 or more wheezing episodes. Selected taxa were chosen for composition analysis, based on their established associations with other allergic disease outcomes. The genus Clostridium was under-represented among infants with two or more wheezing episodes (p=0.04). Preliminary comprehensive analyses revealed that operational taxonomic units (OTUs) belonging to the Families Ruminococcaceae, Rikenellaceae and Lachnospiraceae were over-represented among wheezing infants (all p<0.01). Gut microbiota diversity and richness were not significantly associated with wheeze; these findings were unchanged following adjustment for gender, mode of delivery, breastfeeding, and antibiotic exposure. In this preliminary analysis, we identified several crude differences in microbiota composition among wheezing infants, although a significant association with overall biodiversity was not observed. The long-term clinical relevance of these changes will be the focus of ongoing studies within the CHILD cohort. Detailed and extended assessment of wheeze (including its severity and association with infection and allergic disease), gut microbiota, and relevant environmental exposures will be conducted at different ages throughout childhood.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».