1470 PROGRESSION TO MUSCLE INVASION DURING SURVEILLANCE OF UROTHELIAL CARCINOMA IS ASSOCIATED WITH POOR PROGNOSIS
Notice bibliographique
Résumé
You have accessJournal of UrologyBladder Cancer: Superficial II1 Apr 20101470 PROGRESSION TO MUSCLE INVASION DURING SURVEILLANCE OF UROTHELIAL CARCINOMA IS ASSOCIATED WITH POOR PROGNOSIS Rodney Breau, R. Jeffrey Karnes, Bradley Leibovich, Sarah Farmer, Chris Morash, Ilias Cagiannos, Michael Blute, and Igor Frank Rodney BreauRodney Breau Rochester, MN More articles by this author , R. Jeffrey KarnesR. Jeffrey Karnes Rochester, MN More articles by this author , Bradley LeibovichBradley Leibovich Rochester, MN More articles by this author , Sarah FarmerSarah Farmer Rochester, MN More articles by this author , Chris MorashChris Morash Ottawa, Canada More articles by this author , Ilias CagiannosIlias Cagiannos Ottawa, Canada More articles by this author , Michael BluteMichael Blute Rochester, MN More articles by this author , and Igor FrankIgor Frank Rochester, MN More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.1185AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Despite aggressive surveillance and timely cystectomy, many patients who initially present with non-muscle invasive urothelial carcinoma (UC) eventually experience metastatic progression. The purpose of this study was to evaluate outcomes of patients who present with non-muscle invasive UC and progress to muscle invasion prior to cystectomy. METHODS 981 consecutive cystectomy patients without a history of radiation or systemic chemotherapy were reviewed. Of these, 500 had non-muscle invasive disease at initial presentation. Group 1 (n=310) had cystectomy prior to muscle invasion, Group 2 (n=190) had cystectomy when they progressed to muscle invasion and Group 3 (n=481) had muscle invasion at initial presentation. RESULTS For groups 1 to 3, 5-year cancer-specific survival rates were 85.4%, 52.9% and 62.4% (p<0.001); and 5-year overall survival rates were 70.0%, 42.1% and 49.5% (p<0.001). Of the patients who initially presented with non-muscle invasive disease, progression to muscle invasion was associated with increased risk of cancer specific death (Adjusted HR 2.38; 95% CI 1.6, 3.5). In addition, patients who progressed to muscle invasion on surveillance had worse outcomes compared to patients who initially presented with muscle invasion (overall survival HR 1.3; 95%CI 1.0, 1.5). CONCLUSIONS Despite close surveillance, many patients who progress to muscle invasion will die from UC. Patients who progress to muscle invasion on surveillance seem to have particularly aggressive disease and may benefit from neoadjuvant systemic chemotherapy. © 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e566-e567 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.Metrics Author Information Rodney Breau Rochester, MN More articles by this author R. Jeffrey Karnes Rochester, MN More articles by this author Bradley Leibovich Rochester, MN More articles by this author Sarah Farmer Rochester, MN More articles by this author Chris Morash Ottawa, Canada More articles by this author Ilias Cagiannos Ottawa, Canada More articles by this author Michael Blute Rochester, MN More articles by this author Igor Frank Rochester, MN More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,003 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,008 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».