P3‐116: Intensity of long‐term physical activity and later life cognition in postmenopausal women
Notice bibliographique
Résumé
Long-term strenuous physical activity decreases lifetime exposure to ovarian hormones in women and has been found to play a protective role against breast cancer; however reduction in ovarian hormone exposure has been associated with increased risk of cognitive impairment. Long-term physical activity has been found to be associated with improved cognition but the intensity required to preserve cognition is not known. Our purpose was to examine the associations between both long-term strenuous and moderate activity levels and cognition in recently postmenopausal women. Participants were 90 women aged 50-63 years, 1 to10 years post natural menopause, with no history of breast cancer, HRT use, psychiatric disorder, dementia or other neurological condition. Participants provided information on the amount of strenuous and moderate physical recreational activities in which they engaged during successive periods from high school to menopause. Summary measures of each type of physical activity were constructed. Neuropsychological tests measuring memory and frontal lobe functioning were also administered. Linear regression analyses were conducted for each of 8 neuropsychological outcome measures, adjusted for age, education, reproductive years, cigarette smoking, alcohol consumption, parity, and periods of amenorrhea, to control for potential effects on outcome and exposure to ovarian hormones. Strenuous and moderate activity levels were both included in each of the 8 regression models. Long-term strenuous activity was consistently associated with poorer performance on all 8 of the neuropsychological measures: significant negative associations at p <0.05 were found on tests of semantic memory, working memory, delayed verbal recall, and sustained attention. Moderate activity was consistently associated with better performance on all 8 of the outcome measures: significant positive associations at p <0.05 were found on tests of cognitive flexibility, working memory, and sustained attention. Long-term strenuous activity may increase the risk of cognitive impairment in recently postmenopausal women. Thus strenuous physical activity, while protective for breast cancer, may have deleterious effects on later life cognition whereas moderate long-term physical activity may improve later life cognition. The consistency of the direction of the relationships of these preliminary findings has important implications for lifestyle recommendations and supports the need for large-scale longitudinal studies including both women and men.
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,004 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».