Emerging concepts on neuronal cytoskeleton
Notice bibliographique
Résumé
The Emerging Concepts on Neuronal Cytoskeleton Workshop came from the idea that scientists in the same field should meet regularly to share results and exchange ideas and hypotheses. While there are scientific societies and large meetings that bring together thousands of scientists, small specialized meetings on a specific issue are sometimes infrequent and difficult to attend, especially for graduate and postgraduate students. Accordingly, our Workshop is a great opportunity for Latin American scientists and their trainees to share research on the neuronal cytoskeleton with established researchers coming from all over the world. Our two meetings in 2011 and 2013 have offered a close and friendly environment for interactions and stimulation to forge collaborations among scientists with common goals. Last year, the second workshop was held in Marbella Resort, Maitencillo, Chile from May 26 to 30, 2013. The Program began with a Plenary Lecture by Professor Gary Banker in which he presented his historic and continuing development of hippocampal primary neuronal culture, which is the basis for much significant cellular and molecular neurobiology. Nine sessions of talks and discussions over the next three days considered the roles of the neuronal cytoskeleton in development, maturation and disease states. Oral presentations were given by 29 internationally recognized researchers, and three poster sessions were held for graduate students, postdoctoral trainees and young researchers. The meeting involved 80 participants from Argentina, Brazil, Canada, Colombia, Chile, France, India, Mexico, Portugal, UK, Uruguay, and USA. In this issue of Journal of Neurochemistry, aspects of the spirit of the workshop are presented. Five review articles summarize emerging ideas on several functions of the neuronal cytoskeleton. Don Arnold and Gianluca Gallo describe coordinated functions of axonal myosin and actin (Arnold and Gallo 2014): axonal actin patches are precursors for protrusion and anchorage sites for myosin motors and their cargos, while axonal rings of actin and spectrin are scaffolds for stabilizing and organizing axonal components. Eric Dent and Peter Baas (Dent and Baas 2014) propose new ideas for microtubule function. In addition to well-known roles in cytoskeletal support and transport, neuronal microtubules may have dynamic roles in signaling and mediating plasticity in axons, dendrites, and spines. Timothy Gomez and Paul Letourneau review actin dynamics in growth cones (Gomez and Letourneau 2014). The article addresses how actin polymerization and organization is dynamically regulated by extracellular and intracellular stimuli to control growth cone motility. Phillip Gordon-Weeks and Alyson Fournier review the roles of the neuronal cytoskeleton in the modulation of synaptic development, maturation and plasticity, and offer a current vision of the efforts to promote plasticity by targeting the cytoskeleton during neuronal regeneration (Gordon-Weeks and Fournier 2014). Finally, Christian Gonzalez-Billault and Alfredo Caceres review how small GTPases from the Rab family are essential players in linking intracellular membrane trafficking with cytoskeleton dynamics, and their roles in dendrite and axon differentiation (Villarroel-Campos et al. 2014). In closing, we emphasize the highly stimulating environment of the workshop, the growing number of students, and the participation of every attendee in the success of the meeting. We hope you enjoy the articles in this issue written by participants and we look forward with enthusiasm for next meeting on this topic that will take place in 2015 in Puerto Varas, Chile!
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,002 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,001 |
| Bibliométrie | 0,003 | 0,002 |
| Études des sciences et des technologies | 0,001 | 0,004 |
| Communication savante | 0,004 | 0,008 |
| Science ouverte | 0,002 | 0,002 |
| Intégrité de la recherche | 0,004 | 0,006 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,004 | 0,002 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».