Does the incidence of IBD increase when persons move from a low- to a high-risk area?
Notice bibliographique
Résumé
Inflammatory bowel disease (IBD), both Crohn's disease (CD) and ulcerative colitis (UC), are much more common in the countries of Europe and North America.1,2 Over the last several decades CD has been noted in these populations to have increased even further, whereas UC has remained much the same.3 In 1997 an article from the United Kingdom described IBD as essentially being confined to Western countries.4 In North America, Americans of North European descent have more than a 4-fold increased incidence than Americans of African-American descent.1 In this population, Jews of European descent have a 5-fold increase compared to that of Caucasians. Other North American studies have shown that the incidence in Caucasians is much greater than those of African-Americans, which is greater than Asians and those of Hispanic origin.2 In countries of low incidence, e.g., Seoul, Korea, there has been a 10-fold increase in UC since the 1980s.2 To answer the specific question, one needs to study populations in the developing countries, obtain accurate figures for the incidence and prevalence of both CD, and UC and then compare these when migration occurs of these populations to countries where the incidence and prevalence is much higher, that is, in Europe or North America. This migration underscores the impact and importance of environmental risk factors. There is increasing knowledge of the importance of the bacterial population, resident in the human gut, and its influences on IBD. There are now known to be important bacterial epithelial cell interactions that are thought to be involved in the pathogenesis of IBD. There are very few studies of the total population of bacteria in humans but there have been major breakthroughs in the ability to study these bacterial populations and they are now being applied to the IBD populations. As of yet, they have not been applied to countries where the prevalence is low and then restudied in the same people who migrate to countries where the prevalence is high. It will be this kind of crucial information that will pinpoint whether a move from developing to developed countries is accompanied by a corresponding change in colonic bacterial populations. Other possibilities could be the effect of infestations and parasites. The incidence of helminths is known to be high in developing countries and it is postulated that this is a potential factor in keeping the immune status of the individuals continually stimulated such that IBD does not develop.5 Benign eggs from worms have been used to treat CD with successful results in subjects residing in developed countries.6
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,006 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,001 |
| Bibliométrie | 0,001 | 0,002 |
| Études des sciences et des technologies | 0,000 | 0,001 |
| Communication savante | 0,001 | 0,002 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,002 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,004 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».