Hepatic Phosphatidylethanolamine N-Methyltransferase, Unexpected Roles in Animal Biochemistry and Physiology

In 1961, when Bremer and Greenberg (1Bremer J. Greenberg D.M. Biochim. Biophys. Acta. 1961; 46: 205-216Crossref Scopus (357) Google Scholar) characterized the methylation reactions that convert phosphatidylethanolamine (PE) 4The abbreviations used are: PE, phosphatidylethanolamine; PC, phosphatidylcholine; PEMT, phosphatidylethanolamine N-methyltransferase; ER, endoplasmic reticulum; AdoMet, S-adenosylmethionine; CT, CTP:phosphocholine cytidylyltransferase; CD, choline-deficient; TG, triacyglycerol(s); VLDL, very low density lipoprotein; HDL, high density lipoprotein; AdoHcy, S-adenosylhomocysteine; Hcy, homocysteine. 4The abbreviations used are: PE, phosphatidylethanolamine; PC, phosphatidylcholine; PEMT, phosphatidylethanolamine N-methyltransferase; ER, endoplasmic reticulum; AdoMet, S-adenosylmethionine; CT, CTP:phosphocholine cytidylyltransferase; CD, choline-deficient; TG, triacyglycerol(s); VLDL, very low density lipoprotein; HDL, high density lipoprotein; AdoHcy, S-adenosylhomocysteine; Hcy, homocysteine. to phosphatidylcholine (PC), it is unlikely that they would have predicted the physiological impact of this biosynthetic conversion. Similarly, when Ridgway and Vance (2Ridgway N.D. Vance D.E. J. Biol. Chem. 1987; 262: 17231-17239Abstract Full Text PDF PubMed Google Scholar) succeeded in purification of the hepatic enzyme PE N-methyltransferase (PEMT), we considered this enzyme to be important only in the that that to the important of the and impact and of is to the endoplasmic and the of the of the J. Biol. Chem. Full Text PDF PubMed Google Vance Vance D.E. J. Biol. Chem. Full Text PDF PubMed Google the Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google methylation reactions in the of PE to is to the of the Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google of PE to have and is enzyme D.E. Ridgway N.D. PubMed Scopus Google in the is the and J. Biol. Chem. Full Text PDF PubMed Google PubMed Scopus Google is that the enzyme CTP:phosphocholine PubMed Scopus Google Scholar) and Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google Similarly, that Biol. 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Acta. 1961; 46: 205-216Crossref Scopus (357) Google Scholar) characterized the methylation reactions that convert phosphatidylethanolamine (PE) 4The abbreviations used are: PE, phosphatidylethanolamine; PC, phosphatidylcholine; PEMT, phosphatidylethanolamine N-methyltransferase; ER, endoplasmic reticulum; AdoMet, S-adenosylmethionine; CT, CTP:phosphocholine cytidylyltransferase; CD, choline-deficient; TG, triacyglycerol(s); VLDL, very low density lipoprotein; HDL, high density lipoprotein; AdoHcy, S-adenosylhomocysteine; Hcy, homocysteine. 4The abbreviations used are: PE, phosphatidylethanolamine; PC, phosphatidylcholine; PEMT, phosphatidylethanolamine N-methyltransferase; ER, endoplasmic reticulum; AdoMet, S-adenosylmethionine; CT, CTP:phosphocholine cytidylyltransferase; CD, choline-deficient; TG, triacyglycerol(s); VLDL, very low density lipoprotein; HDL, high density lipoprotein; AdoHcy, S-adenosylhomocysteine; Hcy, homocysteine. to phosphatidylcholine (PC), it is unlikely that they would have predicted the physiological impact of this biosynthetic conversion. Similarly, when Ridgway and Vance (2Ridgway N.D. Vance D.E. J. Biol. Chem. 1987; 262: 17231-17239Abstract Full Text PDF PubMed Google Scholar) succeeded in purification of the hepatic enzyme PE N-methyltransferase (PEMT), we considered this enzyme to be important only in the that that to the important of the and impact and of is to the endoplasmic and the of the of the J. Biol. Chem. Full Text PDF PubMed Google Vance Vance D.E. J. Biol. Chem. Full Text PDF PubMed Google the Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google methylation reactions in the of PE to is to the of the Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google of PE to have is to the endoplasmic and the of the of the J. Biol. Chem. Full Text PDF PubMed Google Vance Vance D.E. J. Biol. Chem. Full Text PDF PubMed Google the Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google methylation reactions in the of PE to is to the of the Vance D.E. J. Biol. Chem. 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