Hepatic Phosphatidylethanolamine N-Methyltransferase, Unexpected Roles in Animal Biochemistry and Physiology

In 1961, when Bremer and Greenberg (1Bremer J. Greenberg D.M. Biochim. Biophys. Acta. 1961; 46: 205-216Crossref Scopus (357) Google Scholar) characterized the methylation reactions that convert phosphatidylethanolamine (PE) 4The abbreviations used are: PE, phosphatidylethanolamine; PC, phosphatidylcholine; PEMT, phosphatidylethanolamine N-methyltransferase; ER, endoplasmic reticulum; AdoMet, S-adenosylmethionine; CT, CTP:phosphocholine cytidylyltransferase; CD, choline-deficient; TG, triacyglycerol(s); VLDL, very low density lipoprotein; HDL, high density lipoprotein; AdoHcy, S-adenosylhomocysteine; Hcy, homocysteine. 4The abbreviations used are: PE, phosphatidylethanolamine; PC, phosphatidylcholine; PEMT, phosphatidylethanolamine N-methyltransferase; ER, endoplasmic reticulum; AdoMet, S-adenosylmethionine; CT, CTP:phosphocholine cytidylyltransferase; CD, choline-deficient; TG, triacyglycerol(s); VLDL, very low density lipoprotein; HDL, high density lipoprotein; AdoHcy, S-adenosylhomocysteine; Hcy, homocysteine. to phosphatidylcholine (PC), it is unlikely that they would have predicted the physiological impact of this biosynthetic conversion. Similarly, when Ridgway and Vance (2Ridgway N.D. Vance D.E. J. Biol. Chem. 1987; 262: 17231-17239Abstract Full Text PDF PubMed Google Scholar) succeeded in purification of the hepatic enzyme PE N-methyltransferase (PEMT), we considered this enzyme to be important only in the that that to the important of the and impact and of is to the endoplasmic and the of the of the J. Biol. Chem. Full Text PDF PubMed Google Vance Vance D.E. J. Biol. Chem. Full Text PDF PubMed Google the Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google methylation reactions in the of PE to is to the of the Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google of PE to have and is enzyme D.E. Ridgway N.D. PubMed Scopus Google in the is the and J. Biol. Chem. Full Text PDF PubMed Google PubMed Scopus Google is that the enzyme CTP:phosphocholine PubMed Scopus Google Scholar) and Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google Similarly, that Biol. PubMed Scopus Google the Biochim. Biophys. Acta. PubMed Scopus Google of the of this that is in J. Biol. PubMed Scopus Google of the in the Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google the biosynthetic the in In the the and to this to that is that the and is that the and is to and and Vance D.E. J. Full Text PDF PubMed Google and Vance D.E. PubMed Scopus Google in the the of hepatic and PE and in it that the in the of the we the the Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google of in the that in and the of and that in to when is in the J. Google and the of in and the used to of and PubMed Scopus Google of and is that in and the of the reactions Full Text Full Text PDF PubMed Scopus Google of would only the of PE to in hepatic in J. Google Scholar) to this and that of that is the is PubMed Scopus Google of in the would be the the the of of is in the the in hepatic is is very low density Vance D.E. J. Biol. Chem. Full Text PDF PubMed Google In to the of to we the of the of of the in in Vance D.E. J. Full Text Full Text PDF PubMed Scopus Google of is and Full Text PDF PubMed Scopus Google Scholar) the of the of we the the and that the the they the and Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google the the in the of and the the in to this in PC, in of the that that the of hepatic PE in the the the of PE in the of Vance D.E. Full Text Full Text PDF PubMed Scopus Google the of to PE to in the of in the of the and the of hepatic enzyme that when in in of the of Vance D.E. Full Text Full Text PDF PubMed Scopus Google of and in the of and is PE Vance D.E. Vance of and that the of PC, PE, in the of of the PE the the Vance D.E. Full Text Full Text PDF PubMed Scopus Google the of the in the that would in this we used that PE PubMed Scopus Google the the Vance D.E. Full Text Full Text PDF PubMed Scopus Google the that PE the of in the this Vance D.E. Full Text Full Text PDF PubMed Scopus Google the that of to PE in hepatic to and the and the and Vance D.E. Vance of and that in we used to the of PE in Vance D.E. Full Text Full Text PDF PubMed Scopus Google the PE and the in of the Vance D.E. Full Text Full Text PDF PubMed Scopus Google Similarly, when the the of the and in the that of of the that to of to the of in have that this have in the in hepatic Vance D.E. Full Text Full Text PDF PubMed Scopus Google and hepatic in of of Vance D.E. PubMed Scopus Google and when the of in the have to be Vance D.E. PubMed Scopus Google of to be of Vance D.E. J. PubMed Scopus Google of the in be and this we the of to and and and is of the of Vance D.E. J. Biol. Chem. Full Text PDF PubMed Google Scholar) of and the be Vance D.E. J. Biol. Chem. Full Text PDF PubMed Google only is the is Vance D.E. Vance J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google the of in is the of Vance D.E. Biochim. Biophys. Acta. PubMed Scopus Google Scholar) Vance D.E. Biochim. Biophys. Acta. PubMed Scopus Google Scholar) to in the of the of the of in the of of in Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google In of of in of Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google in that of TG, and in Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google of of in the of this is Vance D.E. J. Full Text Full Text PDF PubMed Scopus Google the is in we the is that in Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google of TG, PC, and and of of in the of that the of Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google the of in the of we be we the that the low density and the high in in the density the density and in is high density of and of in of Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google Similarly, the of in the Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google in in is that of to this in and of HDL, and this the of the of and to have important in hepatic of Vance D.E. Biochim. Biophys. Acta. PubMed Scopus Google of is in and the is that in the is in the of and of the is to the Vance D.E. Biochim. Biophys. Acta. PubMed Scopus Google is in in is to the it be and the to it that to the and in hepatic and of the reactions is is to and the of is the of and J. PubMed Scopus Google Scholar) and PubMed Scopus Google of J. J. PubMed Scopus Google J. J. J. PubMed Scopus Google and J. J. PubMed Scopus Google is that methylation and Full Text Full Text PDF PubMed Scopus Google be that of in and Full Text Full Text PDF PubMed Scopus Google the of in the and we that to of Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google the the of in and the of hepatic and we that Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google have of in the Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google of in the of in of the to the of Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google to the of of the Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google In PE methylation in Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google the in hepatic and in the and in Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google that is in in to the of PE Biochim. Biophys. Acta. PubMed Scopus Google we that the of to would be Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google that the of the of in J. PubMed Google Scholar) and the of the of J. PubMed Scopus Google that PEMT, is important of in of to in is Full Text PDF PubMed Scopus Google Full Text PDF PubMed Scopus Google Vance D.E. J. PubMed Scopus Google Vance D.E. J. PubMed Scopus Google Full Text PDF PubMed Scopus Google Full Text PDF PubMed Scopus Google Scholar) that PE methylation of that of is in J. J. Full Text PDF PubMed Google J. Full Text PDF PubMed Google J. PubMed Scopus Google of this is the Biochim. Biophys. Acta. PubMed Scopus Google J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google to the of is the is in and in to in and and characterized in Vance D.E. J. Full Text PDF PubMed Google the of and J. J. PubMed Scopus Google Scholar) of of in and in the to in the is J. J. PubMed Scopus Google and of the in of the and in of J. J. 46: Full Text Full Text PDF PubMed Scopus Google Scholar) of the and In the and in the J. PubMed Scopus Google in the J. Scopus Google in the J. J. PubMed Scopus Google only the and J. Scopus Google of the the to the to when is J. Scopus Google the in J. J. PubMed Scopus Google to in the the of the of the in that important that in the in of to PE in the when the of is to and in that be the important in the of of in and is In 1961, when Bremer and Greenberg (1Bremer J. Greenberg D.M. Biochim. Biophys. Acta. 1961; 46: 205-216Crossref Scopus (357) Google Scholar) characterized the methylation reactions that convert phosphatidylethanolamine (PE) 4The abbreviations used are: PE, phosphatidylethanolamine; PC, phosphatidylcholine; PEMT, phosphatidylethanolamine N-methyltransferase; ER, endoplasmic reticulum; AdoMet, S-adenosylmethionine; CT, CTP:phosphocholine cytidylyltransferase; CD, choline-deficient; TG, triacyglycerol(s); VLDL, very low density lipoprotein; HDL, high density lipoprotein; AdoHcy, S-adenosylhomocysteine; Hcy, homocysteine. 4The abbreviations used are: PE, phosphatidylethanolamine; PC, phosphatidylcholine; PEMT, phosphatidylethanolamine N-methyltransferase; ER, endoplasmic reticulum; AdoMet, S-adenosylmethionine; CT, CTP:phosphocholine cytidylyltransferase; CD, choline-deficient; TG, triacyglycerol(s); VLDL, very low density lipoprotein; HDL, high density lipoprotein; AdoHcy, S-adenosylhomocysteine; Hcy, homocysteine. to phosphatidylcholine (PC), it is unlikely that they would have predicted the physiological impact of this biosynthetic conversion. Similarly, when Ridgway and Vance (2Ridgway N.D. Vance D.E. J. Biol. Chem. 1987; 262: 17231-17239Abstract Full Text PDF PubMed Google Scholar) succeeded in purification of the hepatic enzyme PE N-methyltransferase (PEMT), we considered this enzyme to be important only in the that that to the important of the and impact and of is to the endoplasmic and the of the of the J. Biol. Chem. Full Text PDF PubMed Google Vance Vance D.E. J. Biol. Chem. Full Text PDF PubMed Google the Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google methylation reactions in the of PE to is to the of the Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google of PE to have is to the endoplasmic and the of the of the J. Biol. Chem. Full Text PDF PubMed Google Vance Vance D.E. J. Biol. Chem. Full Text PDF PubMed Google the Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google methylation reactions in the of PE to is to the of the Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google of PE to have and is enzyme D.E. Ridgway N.D. PubMed Scopus Google in the is the and J. Biol. Chem. Full Text PDF PubMed Google PubMed Scopus Google is that the enzyme CTP:phosphocholine PubMed Scopus Google Scholar) and Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google Similarly, that Biol. PubMed Scopus Google the Biochim. Biophys. Acta. PubMed Scopus Google of the of this that is in J. Biol. PubMed Scopus Google of the in the Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google the biosynthetic the in In the the and to this to that is to and and Vance D.E. J. Full Text PDF PubMed Google and Vance D.E. PubMed Scopus Google in the the of hepatic and PE and in it that the in the of the we the the Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google of in the that in and the of and that in to when is in the J. Google is enzyme D.E. Ridgway N.D. PubMed Scopus Google in the is the and J. Biol. Chem. Full Text PDF PubMed Google PubMed Scopus Google is that the enzyme CTP:phosphocholine PubMed Scopus Google Scholar) and Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google Similarly, that Biol. PubMed Scopus Google the Biochim. Biophys. Acta. PubMed Scopus Google of the of this that is in J. Biol. PubMed Scopus Google of the in the Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google the biosynthetic the in In the the and to this to that is to and and Vance D.E. J. Full Text PDF PubMed Google and Vance D.E. PubMed Scopus Google in the the of hepatic and PE and in it that the in the of the we the the Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google of in the that in and the of and that in to when is in the J. Google PEMT, and the of in and the used to of and PubMed Scopus Google of and is that in and the of the reactions Full Text Full Text PDF PubMed Scopus Google of would only the of PE to in hepatic in J. Google Scholar) to this and that of that is the is PubMed Scopus Google of in the would be the the the of of is in the the in hepatic is is very low density Vance D.E. J. Biol. Chem. Full Text PDF PubMed Google In to the of to we the of the of of the in in Vance D.E. J. Full Text Full Text PDF PubMed Scopus Google of is and Full Text PDF PubMed Scopus Google Scholar) the of the of we the the and that the the they the and Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google the the in the of and the the in to this in PC, in of the that that the of hepatic PE in the the the of PE in the of Vance D.E. Full Text Full Text PDF PubMed Scopus Google the of to PE to in the of in the of the and the of hepatic enzyme that when in in of the of Vance D.E. Full Text Full Text PDF PubMed Scopus Google of and in the of and is PE Vance D.E. Vance of and that the of PC, PE, in the of of the PE the the Vance D.E. Full Text Full Text PDF PubMed Scopus Google the of the in the that would in this we used that PE PubMed Scopus Google the the Vance D.E. Full Text Full Text PDF PubMed Scopus Google the that PE the of in the this Vance D.E. Full Text Full Text PDF PubMed Scopus Google the that of to PE in hepatic to and that in we used to the of PE in Vance D.E. Full Text Full Text PDF PubMed Scopus Google the PE and the in of the Vance D.E. Full Text Full Text PDF PubMed Scopus Google Similarly, when the the of the and in the that of of the that to of to the of in have that this have in the in hepatic Vance D.E. Full Text Full Text PDF PubMed Scopus Google and hepatic in of of Vance D.E. PubMed Scopus Google and when the of in the have to be Vance D.E. PubMed Scopus Google of to be of Vance D.E. J. PubMed Scopus Google of the in be and this we the of to and and the of in and the used to of and PubMed Scopus Google of and is that in and the of the reactions Full Text Full Text PDF PubMed Scopus Google of would only the of PE to in hepatic in J. Google Scholar) to this and that of that is the is PubMed Scopus Google of in the would be the the the of of is in the the in hepatic is is very low density Vance D.E. J. Biol. Chem. Full Text PDF PubMed Google In to the of to we the of the of of the in in Vance D.E. J. Full Text Full Text PDF PubMed Scopus Google of is In and Full Text PDF PubMed Scopus Google Scholar) the of the of we the the and that the the they the and Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google the the in the of and the the in to this in PC, in of the that that the of hepatic PE in the the the of PE in the of Vance D.E. Full Text Full Text PDF PubMed Scopus Google the of to PE to in the of in the of the and the of hepatic enzyme that when in in of the of Vance D.E. Full Text Full Text PDF PubMed Scopus Google of and in the of and is PE Vance D.E. Vance of and that the of PC, PE, in the of of the PE the the Vance D.E. Full Text Full Text PDF PubMed Scopus Google the of the in the that would in this we used that PE PubMed Scopus Google the the Vance D.E. Full Text Full Text PDF PubMed Scopus Google the that PE the of in the this Vance D.E. Full Text Full Text PDF PubMed Scopus Google the that of to PE in hepatic to and that in we used to the of PE in Vance D.E. Full Text Full Text PDF PubMed Scopus Google the PE and the in of the Vance D.E. Full Text Full Text PDF PubMed Scopus Google Similarly, when the the of the and in the that of of the that to of to the of in have that this have in the in hepatic Vance D.E. Full Text Full Text PDF PubMed Scopus Google and hepatic in of of Vance D.E. PubMed Scopus Google and when the of in the have to be Vance D.E. PubMed Scopus Google of to be of Vance D.E. J. PubMed Scopus Google of the in be and this we the of to and and and is of the of Vance D.E. J. Biol. Chem. Full Text PDF PubMed Google Scholar) of and the be Vance D.E. J. Biol. Chem. Full Text PDF PubMed Google only is the is Vance D.E. Vance J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google the of in is the of Vance D.E. Biochim. Biophys. Acta. PubMed Scopus Google Scholar) Vance D.E. Biochim. Biophys. Acta. PubMed Scopus Google Scholar) to in the of the of the of in the of of in Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google In of of in of Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google in that of TG, and in Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google of of in the of this is Vance D.E. J. Full Text Full Text PDF PubMed Scopus Google the is in we the is that in Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google of TG, PC, and and of of in the of that the of Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google the of in the of we be we the that the low density and the high in in the density the density and in is high density of and of in of Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google Similarly, the of in the Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google in in is that of to this in and of HDL, and this the of the of and to have important in hepatic of Vance D.E. Biochim. Biophys. Acta. PubMed Scopus Google of is in and the is that in the is in the of and of the is to the Vance D.E. Biochim. Biophys. Acta. PubMed Scopus Google is in in is to the it be and the to it that to the and in hepatic is of the of Vance D.E. J. Biol. Chem. Full Text PDF PubMed Google Scholar) of and the be Vance D.E. J. Biol. Chem. Full Text PDF PubMed Google only is the is Vance D.E. Vance J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google the of in is the of Vance D.E. Biochim. Biophys. Acta. PubMed Scopus Google Scholar) Vance D.E. Biochim. Biophys. Acta. PubMed Scopus Google Scholar) to in the of the of the of in the of of in Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google In of of in of Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google in that of TG, and in Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google of of in the of this is Vance D.E. J. Full Text Full Text PDF PubMed Scopus Google the is in we the is that in Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google of TG, PC, and and of of in the of that the of Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google the of in the of we be we the that the low density and the high in in the density the density and in is high density of and of in of Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google Similarly, the of in the Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google in in is that of to this in and of HDL, and this the of the of and to have important in hepatic of Vance D.E. Biochim. Biophys. Acta. PubMed Scopus Google of is in and the is that in the is in the of and of the is to the Vance D.E. Biochim. Biophys. Acta. PubMed Scopus Google is in in is to the it be and the to it that to the and in hepatic and of the reactions is is to and the of is the of and J. PubMed Scopus Google Scholar) and PubMed Scopus Google of J. J. PubMed Scopus Google J. J. J. PubMed Scopus Google and J. J. PubMed Scopus Google is that methylation and Full Text Full Text PDF PubMed Scopus Google be that of in and Full Text Full Text PDF PubMed Scopus Google the of in the and we that to of Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google the the of in and the of hepatic and we that Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google have of in the Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google of in the of in of the to the of Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google to the of of the Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google In PE methylation in Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google the in hepatic and in the and in Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google that is in in to the of PE Biochim. Biophys. Acta. PubMed Scopus Google we that the of to would be Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google that the of the of in J. PubMed Google Scholar) and the of the of J. PubMed Scopus Google that PEMT, is important of in of to in is Full Text PDF PubMed Scopus Google Full Text PDF PubMed Scopus Google Vance D.E. J. PubMed Scopus Google Vance D.E. J. PubMed Scopus Google Full Text PDF PubMed Scopus Google Full Text PDF PubMed Scopus Google Scholar) that PE methylation of that of is in J. J. Full Text PDF PubMed Google J. Full Text PDF PubMed Google J. PubMed Scopus Google of this is the Biochim. Biophys. Acta. PubMed Scopus Google J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google to the of is the is in and in to in and of the reactions is is to and the of is the of and J. PubMed Scopus Google Scholar) and PubMed Scopus Google of J. J. PubMed Scopus Google J. J. J. PubMed Scopus Google and J. J. PubMed Scopus Google is that methylation and Full Text Full Text PDF PubMed Scopus Google be that of in and Full Text Full Text PDF PubMed Scopus Google the of in the and we that to of Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google the the of in and the of hepatic and we that Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google have of in the Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google of in the of in of the to the of Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google to the of of In the Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google In PE methylation in Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google the in hepatic and in the and in Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google that is in in to the of PE Biochim. Biophys. Acta. PubMed Scopus Google we that the of to would be Vance D.E. J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google that the of the of in J. PubMed Google Scholar) and the of the of J. PubMed Scopus Google that PEMT, is important of in of to in is Full Text PDF PubMed Scopus Google Full Text PDF PubMed Scopus Google Vance D.E. J. PubMed Scopus Google Vance D.E. J. PubMed Scopus Google Full Text PDF PubMed Scopus Google Full Text PDF PubMed Scopus Google Scholar) that PE methylation of that of is in J. J. Full Text PDF PubMed Google J. Full Text PDF PubMed Google J. PubMed Scopus Google of this is the Biochim. Biophys. Acta. PubMed Scopus Google J. Biol. Chem. Full Text Full Text PDF PubMed Scopus Google to the of is the is in and in to in and and characterized in Vance D.E. J. Full Text PDF PubMed Google the of and J. J. PubMed Scopus Google Scholar) of of in and in the to in the is J. J. PubMed Scopus Google and of the in of the and in of J. J. 46: Full Text Full Text PDF PubMed Scopus Google Scholar) of the and In the and in the J. PubMed Scopus Google in the J. Scopus Google in the J. J. PubMed Scopus Google only the and J. Scopus Google of the the to the to when is J. Scopus Google the in J. J. PubMed Scopus Google to in the the of the of the in characterized in Vance D.E. J. Full Text PDF PubMed Google the of and J. J. PubMed Scopus Google Scholar) of of in and in the to in the is J. J. PubMed Scopus Google and of the in of the and in of J. J. 46: Full Text Full Text PDF PubMed Scopus Google Scholar) of the and In the and in the J. PubMed Scopus Google in the J. Scopus Google in the J. J. PubMed Scopus Google only the and J. Scopus Google of the the to the to when is J. Scopus Google the in J. J. PubMed Scopus Google to in the the of the of the in that important that in the in of to PE in the when the of is to and in that be the important in the of of in and is that important that in the in of to PE in the when the of is to and in that be the important in the of of in and is

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.