The Nuclear Pore Complex as a Transport Machine

nuclear envelope nuclear pore complex nucleoporin ribonucleoprotein nuclear localization signal Nucleocytoplasmic Transport and the Nuclear Pore ComplexUnlike their prokaryotic counterparts, eukaryotic cells separate the nuclear synthesis of DNA and RNA from cytoplasmic protein synthesis with a barrier termed the nuclear envelope (NE).1 The NE is perforated by large proteinaceous assemblies, called nuclear pore complexes (NPCs), which act as the sole gatekeepers controlling the exchange of material between the two locales (reviewed in Ref. 1Wente S.R. Science. 2000; 288: 1374-1377Crossref PubMed as and the of as and the the of the the between the and (reviewed in Ref. 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S.R. 2000; PubMed in the in the the in the of the the of the the of a the the a barrier the of the the of the the of the the and of the by The is the of the and the of the the the is by a of with the large of the of the in the of by the with their the of of the exchange between of the The is a as the the barrier of the is a of the 2000; PubMed The is the nuclear and cytoplasmic of the with the the of 2000; PubMed of a nucleoporin the of complexes PubMed PubMed PubMed and a and two the of the and of the and and in two the nuclear and of the of cells the of eukaryotic Nucleocytoplasmic Transport and the Nuclear Pore ComplexUnlike their prokaryotic counterparts, eukaryotic cells separate the nuclear synthesis of DNA and RNA from cytoplasmic protein synthesis with a barrier termed the nuclear envelope (NE).1 The NE is perforated by large proteinaceous assemblies, called nuclear pore complexes (NPCs), which act as the sole gatekeepers controlling the exchange of material between the two locales (reviewed in Ref. 1Wente S.R. Science. 2000; 288: 1374-1377Crossref PubMed as and the of as and the the of the the between the and (reviewed in Ref. PubMed of called the the of and their is by a of between of is which of the the in and their the exchange of the of the and as a their prokaryotic counterparts, eukaryotic cells separate the nuclear synthesis of DNA and RNA from cytoplasmic protein synthesis with a barrier termed the nuclear envelope (NE).1 The NE is perforated by large proteinaceous assemblies, called nuclear pore complexes (NPCs), which act as the sole gatekeepers controlling the exchange of material between the two locales (reviewed in Ref. 1Wente S.R. Science. 2000; 288: 1374-1377Crossref PubMed as and the of as and the the of the the between the and (reviewed in Ref. 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Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.