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Defining the clinical course of multiple sclerosis

2014· article· en· 3 133 citations· W2105206040 sur OpenAlex· 10.1212/wnl.0000000000000560

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Résumé

Accurate clinical course descriptions (phenotypes) of multiple sclerosis (MS) are important for communication, prognostication, design and recruitment of clinical trials, and treatment decision-making. Standardized descriptions published in 1996 based on a survey of international MS experts provided purely clinical phenotypes based on data and consensus at that time, but imaging and biological correlates were lacking. Increased understanding of MS and its pathology, coupled with general concern that the original descriptors may not adequately reflect more recently identified clinical aspects of the disease, prompted a re-examination of MS disease phenotypes by the International Advisory Committee on Clinical Trials of MS. While imaging and biological markers that might provide objective criteria for separating clinical phenotypes are lacking, we propose refined descriptors that include consideration of disease activity (based on clinical relapse rate and imaging findings) and disease progression. Strategies for future research to better define phenotypes are also outlined.

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La notice

Revue
Neurology
Thématique
Multiple Sclerosis Research Studies
Domaine
Medicine
Établissements canadiens
Organismes subventionnaires
National Institute of Neurological Disorders and StrokeEMD SeronoAcorda TherapeuticsUniversity of CambridgeBayer CanadaNational Institutes of HealthMultiple Sclerosis SocietySchweizerische Multiple Sklerose GesellschaftEisaiNational Institute for Health and Care ResearchNational Research FoundationWolfson FoundationGenentechEuropean CommissionGlenmark PharmaceuticalsMultiple Sclerosis International FederationSanofiGW PharmaceuticalsAlexion PharmaceuticalsMyelin Repair FoundationBayer HealthCareGrifolsF. Hoffmann-La RocheIronwood Pharmaceuticals, IncorporatedEli Lilly and CompanyUniversity of AlabamaWellcome TrustEuropean Committee for Treatment and Research in Multiple SclerosisSanofi GenzymeUniversity of Alabama at BirminghamMedical Research CouncilTeva Pharmaceutical IndustriesGilead SciencesGlaxoSmithKlineUniversity of Texas Health Science Center at HoustonCelgeneNatural Sciences and Engineering Research Council of CanadaPfizerBiogenSerono Symposia International FoundationNovartis Pharmaceuticals CorporationNational Multiple Sclerosis SocietyNational Heart, Lung, and Blood InstituteSun PharmaCleveland ClinicCanadian Institutes of Health ResearchProthenaAmylin Pharmaceuticals
Mots-clés
Multiple sclerosisClinical trialClinical phenotypeDiseaseMedicineClinical diseasePhenotypeMedical physicsPathologyIntensive care medicineBioinformaticsBiologyPsychiatry
Résumé présent dans OpenAlex
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