Lipin-1 and lipin-3 together determine adiposity in vivo
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Lipin proteins and adiposity in mice; metabolic biology.
This studies lipin proteins and adiposity in mice, not research itself.
Mouse genetics of lipin enzymes and adiposity; domain metabolism biology.
Résumé
The lipin protein family of phosphatidate phosphatases has an established role in triacylglycerol synthesis and storage. Physiological roles for lipin-1 and lipin-2 have been identified, but the role of lipin-3 has remained mysterious. Using lipin single- and double-knockout models we identified a cooperative relationship between lipin-3 and lipin-1 that influences adipogenesis in vitro and adiposity in vivo. Furthermore, natural genetic variations in Lpin1 and Lpin3 expression levels across 100 mouse strains correlate with adiposity. Analysis of PAP activity in additional metabolic tissues from lipin single- and double-knockout mice also revealed roles for lipin-1 and lipin-3 in spleen, kidney, and liver, for lipin-1 alone in heart and skeletal muscle, and for lipin-1 and lipin-2 in lung and brain. Our findings establish that lipin-1 and lipin-3 cooperate in vivo to determine adipose tissue PAP activity and adiposity, and may have implications in understanding the protection of lipin-1-deficient humans from overt lipodystrophy.
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La notice
- Revue
- Molecular Metabolism
- Thématique
- Lipid metabolism and biosynthesis
- Domaine
- Biochemistry, Genetics and Molecular Biology
- Établissements canadiens
- University of Alberta
- Organismes subventionnaires
- National Institute of General Medical SciencesNational Human Genome Research InstituteNational Heart, Lung, and Blood InstituteNational Institutes of Health
- Mots-clés
- Adipose tissueIn vivoLipodystrophyAdipogenesisInternal medicineEndocrinologyBiologyCell biologyMedicineImmunologyBiotechnology
- Résumé présent dans OpenAlex
- oui