Selenium absorption and bioactivity in dogs are affected by dietary format
Notice bibliographique
Résumé
Introduction: The main function of the essential trace mineral selenium (Se) is the protective effect against oxidative stress. Raw materials of dog foods vary greatly in their Se concentration and availability and canned diets are formulated with different raw materials than kibble diets. These dietary formats (canned and kibble) also undergo a different type of processing. However, the current recommendation on Se in dog foods is not format specific. Our previous in vitro study already identified dietary format (canned vs. kibble) and protein digestibility as the main determinants of in vitro Se accessibility in dog foods. The present study was designed to evaluate if these findings are reflected in in vivo Se absorption, i.e. the fraction of dietary Se that reaches the systemic circulation, and Se bioactivity, i.e. the amount of Se that can be used for incorporation into enzymes. Material and methods: Twenty-four Labrador retrievers were randomized to four balanced groups in an incomplete cross-over design in which they were fed 4 of 8 diets during 6 transition days and 29-43 experimental days. The 8 diets were commercially available and varied in format (canned or kibble) and crude protein (CP) concentration. For every format, diets with an intended concentration of 9.6, 14.3, 19.1 and 23.9 g CP/MJ ME were selected. At the end of every feeding period, blood, urine and faecal samples were collected. Blood was analysed for whole blood glutathione peroxidase (GPx) and serum Se. Urine samples were analysed for total Se and creatinine (CT) and faeces for Se. Apparent Se absorption was calculated as the percentage of Se intake that was not found in the faeces. Data were analysed using linear mixed effects models to investigate the effects of actual CP intake, format and their interaction. Results and discussion: The average dietary Se content of the canned and kibble diets was 40.6 and 22.3 µg/MJ ME, respectively. Canned diets also had a higher dietary Se content in our in vitro study; 34.8 µg/MJ ME in canned (n=20) vs. 22.5 µg/MJ ME in kibble diets (n=23). This indicates that a higher dietary Se content is inherent to canned diets. Both apparent Se absorption (as % of Se intake) and urinary Se excretion corrected for the absolute amount of absorbed Se were lower in canned compared to kibble diets (p<0.001 and p<0.001, resp.). The former is in accordance with our in vitro Se accessibility findings(3). In contrast to the in vitro study, CP did not have a significant impact on Se absorption (p=0.753). The potential bioactivity was higher in canned than in kibble diets and decreased with increasing CP intake as measured by GPx (p<0.001 and p<0.001, resp.). This may be partly attributed to the higher amount of dietary Se in canned diets. Conclusion: This study demonstrated that kibble diets result in a higher percentage of apparent Se absorption, but that feeding canned diets causes a higher absolute amount of biologically active Se (in this study measured as GPx). Therefore, recommended allowances for Se should take dietary format into account.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,014 | 0,020 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,002 |
| Science ouverte | 0,001 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».