P-071 Quality of Sleep in Chilean IBD Patients
Notice bibliographique
Résumé
Etiology of Inflammatory Bowel Disease (IBD) is unknown. Genetic, environmental and immunologic factors are probably involved in development of the disease and its clinical course. Some studies have suggested that poor quality of sleep (QS) could play a role in IBD. The aim of our study was to determine QS in patients with IBD, and assess its association with disease activity, compared to patients with Irritable Bowel Syndrome (IBS) and healthy controls. We conducted a cross-sectional, observational cohort pilot study between April and July 2015. Patients with Ulcerative Colitis (UC) or Crohn's Disease (CD) that visited our IBD Program at Clinica Las Condes were invited to participate. Patients with IBS, fulfilling Rome III criteria, were enrolled from the Gastroenterology outpatient clinic, as well as healthy controls. Demographic variables as age, gender and smoking were assessed. In IBD patients, we also collected data on disease related variables including diagnosis, years of disease, Montreal classification, extraintestinal manifestations, hospitalization or surgery due to IBD in the last month, and medical treatment. All the patients answered the Pittsburgh Sleep Quality Index (PSQI) questionnaire, to assess QS. Patients with a PSQI >5 were considered “poor sleepers.” Disease activity of IBD patients was determined by Harvey-Bradshaw Index in CD patients (remission <4) and Modified Mayo Clinical Score (remission = 0) in patients with UC. For statistical analysis frequency and percentage were used. Comparisons between groups for dichotomous variables were performed by chi2 test, and for continuous variables with not normal distribution Mann–Whitney U test (2 variables) or Kruskal–Wallis (more than 2). A P value <0.05 was considered as statistically significant. A total of 276 patients were enrolled (111 IBD, 85 IBS and 80 healthy subjects), observing a poor QS in 66%, 67% and 55% of patients, respectively. The mean PSQI was significantly higher in patients with IBD and IBS compared to healthy controls (7, 7 versus 6; P = 0.014). When comparing IBD patients and IBS patients with healthy controls, independently using Mann–Whitney test, the results are: IBD versus healthy controls P = 0.009, IBS versus healthy controls P = 0.011 and IBD versus IBS P = 0.960. When analyzing demographic and clinical characteristics in IBD patients by QS, there were no differences between poor and good sleepers. IBD patients with active disease had a clearly worse QS than patients in remission (mean PSQI 9 [2–18] versus 6 [1–17], P = 0.005). Sleep disturbances are frequent in IBD and IBS patients compared to healthy controls, observing worse QS in IBD patients with active disease. Therefore, QS should be routinely assessed in IBD patients hence it might influence quality of life of these patients. Prospective studies are needed to investigate if untreated sleep disturbances affect the disease course of IBD.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,005 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».