P-071 Quality of Sleep in Chilean IBD Patients
Bibliographic record
Abstract
Etiology of Inflammatory Bowel Disease (IBD) is unknown. Genetic, environmental and immunologic factors are probably involved in development of the disease and its clinical course. Some studies have suggested that poor quality of sleep (QS) could play a role in IBD. The aim of our study was to determine QS in patients with IBD, and assess its association with disease activity, compared to patients with Irritable Bowel Syndrome (IBS) and healthy controls. We conducted a cross-sectional, observational cohort pilot study between April and July 2015. Patients with Ulcerative Colitis (UC) or Crohn's Disease (CD) that visited our IBD Program at Clinica Las Condes were invited to participate. Patients with IBS, fulfilling Rome III criteria, were enrolled from the Gastroenterology outpatient clinic, as well as healthy controls. Demographic variables as age, gender and smoking were assessed. In IBD patients, we also collected data on disease related variables including diagnosis, years of disease, Montreal classification, extraintestinal manifestations, hospitalization or surgery due to IBD in the last month, and medical treatment. All the patients answered the Pittsburgh Sleep Quality Index (PSQI) questionnaire, to assess QS. Patients with a PSQI >5 were considered “poor sleepers.” Disease activity of IBD patients was determined by Harvey-Bradshaw Index in CD patients (remission <4) and Modified Mayo Clinical Score (remission = 0) in patients with UC. For statistical analysis frequency and percentage were used. Comparisons between groups for dichotomous variables were performed by chi2 test, and for continuous variables with not normal distribution Mann–Whitney U test (2 variables) or Kruskal–Wallis (more than 2). A P value <0.05 was considered as statistically significant. A total of 276 patients were enrolled (111 IBD, 85 IBS and 80 healthy subjects), observing a poor QS in 66%, 67% and 55% of patients, respectively. The mean PSQI was significantly higher in patients with IBD and IBS compared to healthy controls (7, 7 versus 6; P = 0.014). When comparing IBD patients and IBS patients with healthy controls, independently using Mann–Whitney test, the results are: IBD versus healthy controls P = 0.009, IBS versus healthy controls P = 0.011 and IBD versus IBS P = 0.960. When analyzing demographic and clinical characteristics in IBD patients by QS, there were no differences between poor and good sleepers. IBD patients with active disease had a clearly worse QS than patients in remission (mean PSQI 9 [2–18] versus 6 [1–17], P = 0.005). Sleep disturbances are frequent in IBD and IBS patients compared to healthy controls, observing worse QS in IBD patients with active disease. Therefore, QS should be routinely assessed in IBD patients hence it might influence quality of life of these patients. Prospective studies are needed to investigate if untreated sleep disturbances affect the disease course of IBD.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.005 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".