MP81-08 LONG-TERM OUTCOMES IN PARATESTICULAR SARCOMA: A ROLE FOR HEMISCROTECTOMY
Notice bibliographique
Résumé
You have accessJournal of UrologySexual Function/Dysfunction: Penis/Testis/Urethra: Benign Disease & Malignant Disease II1 Apr 2016MP81-08 LONG-TERM OUTCOMES IN PARATESTICULAR SARCOMA: A ROLE FOR HEMISCROTECTOMY Lih-Ming Wong, Brendan Dickson, Charles Catton, Stanley Yap, Thamir Alkasab, Robert Hamilton, and Michael Jewett Lih-Ming WongLih-Ming Wong More articles by this author , Brendan DicksonBrendan Dickson More articles by this author , Charles CattonCharles Catton More articles by this author , Stanley YapStanley Yap More articles by this author , Thamir AlkasabThamir Alkasab More articles by this author , Robert HamiltonRobert Hamilton More articles by this author , and Michael JewettMichael Jewett More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.2061AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Paratesticular sarcoma (PTS) represents a heterogeneous and uncommon group of neoplasms. The literature is confined to small case series with short follow-up. Herein we present an update on our institution’s experience in the management of patients with PTS. METHODS Patients with PTS managed at Princess Margaret Cancer Center, between 1990-2012 were identified from retrospective chart and pathology archive review. Important relevant clinical pathological variables were collected with study endpoints being local recurrence (LR), metastasis and overall survival. Hemiscrotectomy (Fig 1) was offered either as primary (sarcoma diagnosed after percutaneous transcrotal needle biopsy), completion (after prior unplanned surgery), or as salvage for local recurrence. Central pathology review of available slides was performed and all patients were discussed at a multidisciplinary meeting. Mortality data was obtained from Cancer Care Ontario. Univariate analysis of variables associated with survival end points was performed with Cox proportional hazards regression. RESULTS Our cohort had 51 men with a median follow-up of 11.02 years (IQR 4.3-18.2). At last follow-up, 21.6% (n=11) of the patients were deceased with 8 cases attributable to PTS. Median overall survival was 13.9 years. At presentation 92.2% (n=47) of men had localized disease. Completion hemiscrotectomy performed in 25 men found 20% had residual disease present. LR occurred in 12 patients, and with salvage surgery +/- pre-operative radiotherapy, 11/12 were rendered local disease free. Univariate Cox proportional hazards analysis for LR found no hemiscrotectomy (HR 0.21, p=0.02) and positive margin status at initial surgery (HR 4.81, p=0.047) as significant. Metastasis was detected in 10 men (median time to metastasis =18 months), with median time from metastasis to death 11.4 months. CONCLUSIONS The majority of men present with clinically localized PTS and are potentially curable. Early surgery with sarcoma intent may reduce risk of LR with resultant good disease free survival. Alternatively, surveillance with salvage surgery for LR achieves good local control but these patients risk development of metastases and subsequent death from PTS. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e1055-e1056 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Lih-Ming Wong More articles by this author Brendan Dickson More articles by this author Charles Catton More articles by this author Stanley Yap More articles by this author Thamir Alkasab More articles by this author Robert Hamilton More articles by this author Michael Jewett More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,003 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,000 | 0,001 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,022 | 0,003 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».