MP81-08 LONG-TERM OUTCOMES IN PARATESTICULAR SARCOMA: A ROLE FOR HEMISCROTECTOMY
Bibliographic record
Abstract
You have accessJournal of UrologySexual Function/Dysfunction: Penis/Testis/Urethra: Benign Disease & Malignant Disease II1 Apr 2016MP81-08 LONG-TERM OUTCOMES IN PARATESTICULAR SARCOMA: A ROLE FOR HEMISCROTECTOMY Lih-Ming Wong, Brendan Dickson, Charles Catton, Stanley Yap, Thamir Alkasab, Robert Hamilton, and Michael Jewett Lih-Ming WongLih-Ming Wong More articles by this author , Brendan DicksonBrendan Dickson More articles by this author , Charles CattonCharles Catton More articles by this author , Stanley YapStanley Yap More articles by this author , Thamir AlkasabThamir Alkasab More articles by this author , Robert HamiltonRobert Hamilton More articles by this author , and Michael JewettMichael Jewett More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.2061AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Paratesticular sarcoma (PTS) represents a heterogeneous and uncommon group of neoplasms. The literature is confined to small case series with short follow-up. Herein we present an update on our institution’s experience in the management of patients with PTS. METHODS Patients with PTS managed at Princess Margaret Cancer Center, between 1990-2012 were identified from retrospective chart and pathology archive review. Important relevant clinical pathological variables were collected with study endpoints being local recurrence (LR), metastasis and overall survival. Hemiscrotectomy (Fig 1) was offered either as primary (sarcoma diagnosed after percutaneous transcrotal needle biopsy), completion (after prior unplanned surgery), or as salvage for local recurrence. Central pathology review of available slides was performed and all patients were discussed at a multidisciplinary meeting. Mortality data was obtained from Cancer Care Ontario. Univariate analysis of variables associated with survival end points was performed with Cox proportional hazards regression. RESULTS Our cohort had 51 men with a median follow-up of 11.02 years (IQR 4.3-18.2). At last follow-up, 21.6% (n=11) of the patients were deceased with 8 cases attributable to PTS. Median overall survival was 13.9 years. At presentation 92.2% (n=47) of men had localized disease. Completion hemiscrotectomy performed in 25 men found 20% had residual disease present. LR occurred in 12 patients, and with salvage surgery +/- pre-operative radiotherapy, 11/12 were rendered local disease free. Univariate Cox proportional hazards analysis for LR found no hemiscrotectomy (HR 0.21, p=0.02) and positive margin status at initial surgery (HR 4.81, p=0.047) as significant. Metastasis was detected in 10 men (median time to metastasis =18 months), with median time from metastasis to death 11.4 months. CONCLUSIONS The majority of men present with clinically localized PTS and are potentially curable. Early surgery with sarcoma intent may reduce risk of LR with resultant good disease free survival. Alternatively, surveillance with salvage surgery for LR achieves good local control but these patients risk development of metastases and subsequent death from PTS. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e1055-e1056 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Lih-Ming Wong More articles by this author Brendan Dickson More articles by this author Charles Catton More articles by this author Stanley Yap More articles by this author Thamir Alkasab More articles by this author Robert Hamilton More articles by this author Michael Jewett More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.022 | 0.003 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".