Vasculitis: The True and Near-true
Notice bibliographique
Résumé
To the Editor: Ours is a simple observational study (1), which was conceived to shed light on a question raised by our Fellow at the time of signout. None of us had previously published on, nor even much considered, the controversy behind the existence of actinic granuloma. Our null hypothesis was that actinic granuloma is granuloma annulare, and that the only difference between the two concepts is the presence of elastophagocytosis and loss of elastic tissue in the former. Our observation was that lesions with loss of elastic tissue (actinic granuloma) do, in fact, differ from lesions of granuloma annulare in a number of additional ways. The typical lesion of actinic granuloma shows sarcoidal granulomata confined to the level of elastosis in the superficial dermis, contains numerous multinucleate histiocytes, and lacks mucin; the typical lesion of granuloma annulare shows palisading granulomata with central mucin accumulation, has few multinucleate histiocytes, and bears no discernible spatial relationship to the elastotic material. We end the study with hypotheses that spring from these observations: that actinic granuloma represents histiocyte-mediated destruction of actinically-altered elastic tissue, and that granuloma annulare represents a histiocytic reaction to a focus of relatively indestructible altered collagen. There is indeed some degree of histologic overlap between actinic granuloma and granuloma annulare, as there is between innumerable inflammatory dermatoses; however, by appropriate statistical analysis of the differences along a variety of parameters, we have shown that each difference is unlikely to be a random finding. By evaluating our observations with a “cursory glance” and interpreting multiple statistically significant differences as “negligible”, Dr. Ackerman has chosen the path of obfuscation rather than elucidation. As the remainder of Dr. Ackerman's discussion does not refer directly to our findings, we will refrain from commenting on it in detail. Differences of opinion are bound to persist between those who pursue a pragmatic approach based on hypothesis testing by methodical observation, and those who pursue a philosophical approach based on metaphor, analogy and historical context. In closing, we choose not to persuade, but rather to invite readers to reexamine, with an inquisitive eye, the observations and arguments presented in our study and in Dr. Ackerman's commentary. We hope that a more accurate understanding of this interesting concept will be the result. Ibrahim A. Al-Hoqail, M.D. Magda Martinka, M.D. Richard I. Crawford, M.D.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,001 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».