346 DO ASIAN AND CAUCASIAN MEN DEVELOP HIGH GRADE (GLEASON &[GE]7) PROSTATE CANCER AT THE SAME AGE? AN AUTOPSY STUDY
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Résumé
You have accessJournal of UrologyProstate Cancer: Epidemiology & Natural History (II)1 Apr 2013346 DO ASIAN AND CAUCASIAN MEN DEVELOP HIGH GRADE (GLEASON &[GE]7) PROSTATE CANCER AT THE SAME AGE? AN AUTOPSY STUDY Alexandre R Zlotta, Shin Egawa, Dmitry Pushkar, Alexander Govorov, Takahiro Kimura, Masahito Kido, Hiroyuki Takahashi, Cynthia Kuk, Marta Kovylina, Najla Aldaoud, Neil E Fleshner, Antonio Finelli, Laurence Klotz, Jenna Sykes, Gina Lockwood, and Theodorus H van der Kwast Alexandre R ZlottaAlexandre R Zlotta Toronto, Canada , Shin EgawaShin Egawa Tokyo, Japan , Dmitry PushkarDmitry Pushkar Moscow, Russian Federation , Alexander GovorovAlexander Govorov Moscow, Russian Federation , Takahiro KimuraTakahiro Kimura Tokyo, Japan , Masahito KidoMasahito Kido Tokyo, Japan , Hiroyuki TakahashiHiroyuki Takahashi Tokyo, Japan , Cynthia KukCynthia Kuk Toronto, Canada , Marta KovylinaMarta Kovylina Moscow, Russian Federation , Najla AldaoudNajla Aldaoud Toronto, Canada , Neil E FleshnerNeil E Fleshner Toronto, Canada , Antonio FinelliAntonio Finelli Toronto, Canada , Laurence KlotzLaurence Klotz Toronto, Canada , Jenna SykesJenna Sykes Toronto, Canada , Gina LockwoodGina Lockwood Toronto, Canada , and Theodorus H van der KwastTheodorus H van der Kwast Toronto, Canada View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.1732AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES We have previously demonstrated that PCa prevalence is similar between Russian Caucasians and Japanese Asian men. We had chosen a specific Caucasian population in Russia with low penetrance of PSA screening. Autopsy data in North America and Western Europe would have been heavily contaminated due to opportunistic PSA screening. Screening in Japan is also uncommon. Here our aim was to compare the prevalence of Gleason ≥7 PCa on autopsy in Caucasian and Asian men. METHODS 320 prostate glands were prospectively collected during autopsy from men who died from causes other than PCa in Moscow (Russia n=220)-(CAU) and Tokyo (Japan n=100)-(ASI). The same harvesting methodology was followed in both sites. Prostates were removed en-block with the seminal vesicles within 24 hours of death and analyzed in toto (perpendicular sections at 4 mm intervals) by an experienced uro-pathologist. We compared across the ASI and CAU populations, the prevalence of GS≥7 PCa over the various age groups. RESULTS Overall, 37 out of 117 tumors (31.6%) were GS≥7, with a significantly higher proportion in ASI men (51.4%) compared to CAU men (23.2%, p=0.003). Fig 1 illustrates the prevalence of GS≥7 PCa in ASI and CAU men according to age. Compared to CAU, in our autopsy cohort, a higher prevalence of GS≥7 PCa was observed at a later age among ASI with a steeper increase in prevalence by the decade. Breaking down GS7 into (3+4) or (4+3), among 14 GS7 in ASI, 13 were 3+4 and 1 was 4+3. Among 16 CAU with GS7, 10 and 6 were 3+4 and 4+3, respectively, (p=0.086). Limitations include small population size and the absence of Caucasian men aged 80+. CONCLUSIONS A higher proportion of autopsy detected PCa in Asian men is GS≥7 compared to Caucasians. Asian men seem to have a higher prevalence of GS≥7 PCa at a later decade in life compared to Caucasian men. A hypothesis is that in Asian men, the grade progression is much faster than in Caucasian men. The alternative hypothesis would be a de novo origin of GS≥7 instead of grade progression. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e140 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Alexandre R Zlotta Toronto, Canada More articles by this author Shin Egawa Tokyo, Japan More articles by this author Dmitry Pushkar Moscow, Russian Federation More articles by this author Alexander Govorov Moscow, Russian Federation More articles by this author Takahiro Kimura Tokyo, Japan More articles by this author Masahito Kido Tokyo, Japan More articles by this author Hiroyuki Takahashi Tokyo, Japan More articles by this author Cynthia Kuk Toronto, Canada More articles by this author Marta Kovylina Moscow, Russian Federation More articles by this author Najla Aldaoud Toronto, Canada More articles by this author Neil E Fleshner Toronto, Canada More articles by this author Antonio Finelli Toronto, Canada More articles by this author Laurence Klotz Toronto, Canada More articles by this author Jenna Sykes Toronto, Canada More articles by this author Gina Lockwood Toronto, Canada More articles by this author Theodorus H van der Kwast Toronto, Canada More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,000 | 0,001 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».