286Cardioprotective potential of subcutaneous and visceral adipose-derived stem cells
Notice bibliographique
Résumé
Background: Adipose-derived stem cells (ASC) from both subcutaneous and visceral adipose tissues have been studied individually and separately. No studies have been performed to directly compare their biological properties and therapeutic function in treatment of congestive heart failure (CHF). This study was therefore designed to comparatively analyze their biological properties and cardiac therapeutic function. Methods: Rat subcutaneous and visceral adipose tissues were excised for isolation of ASC. Morphology, yield, proliferation, surface markers, differentiation potential, and cytokine secretion of the subcutaneous ASC (S-ASC) and visceral ASC (V-ASC) were analyzed. To assess their therapeutic capacity, a rat model of myocardial infarction (MI) was established by occlusion of the LAD. Seven days after the LAD occlusion, S-ASC (n = 11), V-ASC (n = 11), and cell culture medium (n = 7) were injected into the infarct rim, respectively. Cardiac function of the infarcted hearts was then monitored with MRI for six months. Results: Both S-ASC and V-ASC exhibited a fibroblast-like morphology and expressed stromal cell markers (CD29, 90 and 105). No significant expression of hematopoietic markers (CD11b, 34 and 45) was detected. Under appropriate conditions, both cells could differentiate to adipocyte- and osteocyte-like cells. Both of them expressed a significant level of HGF, IGF and VEGF. As to their differences, visceral fat tissue had a 3-times greater yield of ASC relative to subcutaneous fat. Moreover, V-ASC showed a lower colony-formation rate (9.8±1.0%) compared to S-ASC (13.5±2.6%). In contrast, S-ASC showed a significantly greater growth rate (Doubling time, 17.9±0.9 hours in first two weeks) relative to V-ASC (Doubling time, 26.0±2.6 hours in first two weeks). Both S-ASC and V-ASC-treated hearts showed a significantly greater left ventricular ejection fraction (LVEF, 58.3±14.5% and 56.7±3.1%) than the control hearts (LVEF, 47.2±15.9%) at end of six months of recovery period. LVEF between the two ASC-treated groups was not significantly different. Finally, the implanted stem cells were readily detected in vivo with MRI for 6 months. Myocardial tissue sections showed existence of ASC and their locations matched with MRI signals. Conclusions: S-ASC and V-ASC share several major biological characteristics. Both provide comparable significant improvement on cardiac function. We conclude that the subcutaneous and visceral adipose tissues are equally effective cell sources for cell therapy of congestive heart failure.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,003 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,002 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».