Control study on the cognitive and autonomic nerve function in the elderly depression patients before and after drug intervention
Notice bibliographique
Résumé
Objective To explore the cognitive and autonomic nerve function of elderly geriatric depression( GD) before and after drug intervention. Methods 43 patients with GD were carried out cognitive potential P300,sympathetic skin response( SSR),Hamilton Depression Scale 24( HAMD),the Montreal Cognitive Assessment Scale( MoCA) and the activities of daily living scale( ADL) before and after treatment respectively. 41 healthy elderly people( control group) were investigated all of the above measurements on the day of physical examination. Results Compared with control group,HAMD total score and ADL score were significant higher in study group before treatment; ERP( N2 and P3 latency period,P3 amplitude) and SSR( amplitude and latency period) were significantly different( P 0. 05) between control group and study group before treatment; MoCA total score and all factor scores( attention,visual-spatial and executive function,language,naming,orientation,delayed memory and abstract) were significant lower in study group before treatment than those of control group. There were significant differences in HAMD scale,ADL scale,ERP( N2 and P3 latency period,P3 amplitude) and SSR( amplitude and latency period) between before and after treatment in GD. Compared with before treatment,MoCA total score and factor scores( attention,language,naming,orientation and abstract) were significant higher after treatment,but there were no significant difference before and after treatment in visual-spatial and executive function and delayed memory. Compared with control group,there were no significant difference in study group after treatment in HAMD total score and ERP( N2 and P3 latency period,P3 amplitude); and there were significantly difference in SSR( amplitude and latency period)( P 0. 05) between control and study group after treatment. There were significantly different between study group after treatment and control group in ADL score,MoCA total score and all factor scores( attention,visualspatial and executive function,language,naming,orientation,delayed memory and abstract). N2,P3 latency period were significantly positive related with SSR latency period,and the P3 amplitude was significantly positive related with SSR amplitude( r = 0. 394 ~ 0. 472,P 0. 01) in study group before treatment. The P3 amplitude was significantly negative related with SSR latency period,as well as N2,P3 latency period were all significantly negative related with SSR amplitude( r =- 0. 399 ~- 0. 422,P 0. 01) in study group before treatment. Conclusions There are cognitive function impairment and autonomic nervous system dysfunction in elderly patients with GD,but also there is a relevance between the two function impairments. After treatment with the drug,cognitive function and autonomic nervous function can be improved partly. Cognitive function and autonomic nerve recovery may be later than improvement of depression symptoms.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».