Control study on the cognitive and autonomic nerve function in the elderly depression patients before and after drug intervention
Bibliographic record
Abstract
Objective To explore the cognitive and autonomic nerve function of elderly geriatric depression( GD) before and after drug intervention. Methods 43 patients with GD were carried out cognitive potential P300,sympathetic skin response( SSR),Hamilton Depression Scale 24( HAMD),the Montreal Cognitive Assessment Scale( MoCA) and the activities of daily living scale( ADL) before and after treatment respectively. 41 healthy elderly people( control group) were investigated all of the above measurements on the day of physical examination. Results Compared with control group,HAMD total score and ADL score were significant higher in study group before treatment; ERP( N2 and P3 latency period,P3 amplitude) and SSR( amplitude and latency period) were significantly different( P 0. 05) between control group and study group before treatment; MoCA total score and all factor scores( attention,visual-spatial and executive function,language,naming,orientation,delayed memory and abstract) were significant lower in study group before treatment than those of control group. There were significant differences in HAMD scale,ADL scale,ERP( N2 and P3 latency period,P3 amplitude) and SSR( amplitude and latency period) between before and after treatment in GD. Compared with before treatment,MoCA total score and factor scores( attention,language,naming,orientation and abstract) were significant higher after treatment,but there were no significant difference before and after treatment in visual-spatial and executive function and delayed memory. Compared with control group,there were no significant difference in study group after treatment in HAMD total score and ERP( N2 and P3 latency period,P3 amplitude); and there were significantly difference in SSR( amplitude and latency period)( P 0. 05) between control and study group after treatment. There were significantly different between study group after treatment and control group in ADL score,MoCA total score and all factor scores( attention,visualspatial and executive function,language,naming,orientation,delayed memory and abstract). N2,P3 latency period were significantly positive related with SSR latency period,and the P3 amplitude was significantly positive related with SSR amplitude( r = 0. 394 ~ 0. 472,P 0. 01) in study group before treatment. The P3 amplitude was significantly negative related with SSR latency period,as well as N2,P3 latency period were all significantly negative related with SSR amplitude( r =- 0. 399 ~- 0. 422,P 0. 01) in study group before treatment. Conclusions There are cognitive function impairment and autonomic nervous system dysfunction in elderly patients with GD,but also there is a relevance between the two function impairments. After treatment with the drug,cognitive function and autonomic nervous function can be improved partly. Cognitive function and autonomic nerve recovery may be later than improvement of depression symptoms.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".