Study on the correlation of autonomic dysfunction with motor symptoms and non-motor symptoms in patients with Parkinson's disease
Notice bibliographique
Résumé
Objective To explore the correlation of autonomic dysfunction with motor symptoms and non-motor symptoms in patients with Parkinson's disease(PD). Methods 243 PD patients were recruited in the department of neurology, Beijing Tiantan Hospital from June 2010 to June 2012 and evaluated by the Scale For Outcomes in PD For Autonomic Symptoms(SCOPA-AUT), Unified Parkinson's Disease Rating Scale(UPDRS) Ⅲ, Hoehn-Yahr(H-Y) Staging, Hamilton Anxiety Scale(HAMA),Hamilton Depression Scale(HAMD), Montreal Cognitive Assessment(MoCA), Mini-Mental State Examination(MMSE), Pittsburgh Sleep Quality Index(PSQI), Fatigue Scale-14(FS-14), Activity of Daily Living(ADL) and 39-item Parkinson's Disease Questionnaire(PDQL-39), and correlations of SCOPA-AUT score with above scales scores were performed. Results(1) SCOPA-AUT score of PD patients was 36.6±8.0(23-67)points; SCOPA-AUT score was positively correlated with the age of onset, average of(59.8±10.1) years, and disease duration,average of(3.8±4.0)years(r=0.248, P=0.000; r=0.234, P=0.000);(2)Autonomic symptoms with the highest incidence was gastrointestinal dysfunction(83.5%), among which, constipation was the most frequent(56.4%), which was followed by urinary dysfunction(79.0%), sexual dysfunction(78.6%), cardiovascular dysfunction(48.6%)and thermoregulatory dysfunction(47.3%);(3)SCOPA-AUT score was positively correlated with H-Y Stage(2.0±0.8) and UPDRSⅢ score,(25.9±13.2)points(r=0.390, P=0.000; r=0.425, P=0.000);(4)169 cases were with depression and 154 cases with anxiety; SCOPA-AUT score was positively correlated with scores of HAMD and HADA(r=0.457, P=0.000; r=0.490, P=0.000);(5) 33 cases were PD with no cognitive impairment(PD-NCI), 96 were PD with mild cognitive impairment(PD-MCI) and 114 were PD with dementia(PDD); SCOPA-AUT scores in PD-NCI, PD-MCI and PDD groups were significantly increased in turn,(34.8±7.3)points,(37.9±8.0)points and(38.5±8.7)points, P=0.011;(6) 169 cases were with sleep disorders, which SCOPA-AUT score was positively correlated with PSQI score(r=0.508, P=0.000);(7) 215 cases were with fatigue, which SCOPA-AUT score was positively correlated with FS-14 score(r=0.423, P=0.000);(8)ADL score was(35.3±13.6)points, which was positively correlated with SCOPA-AUT score(r=0.391, P=0.000); PDQL-39 score was(134.1±26.6)points, which was negtively correlated with SCOPA-AUT score(r=―0.649, P=0.000). Conclusions PD patients have high incidence of autonomic dysfunction with multiple symptoms. Autonomic dysfunction is closely correlated with the age of onset, disease duration, motor symptoms and non-motor symptoms, including cognition impairment, anxiety, depression, sleep disorder and fatigue, and dramatically compromises ADL and QOL for PD patients.
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Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
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