Erythropoietin Is Equally Effective as Blood Transfusion at Reducing Infarct Size in Anemic Rats.
Notice bibliographique
Résumé
Abstract Abstract 639 Background: In acute myocardial infarction (MI), anemia may exacerbate ischemia, increasing tissue injury. Red blood cell (RBC) transfusion is currently the only therapeutic intervention to acutely correct anemia. Erythropoietin (EPO) has previously been shown to be cardioprotective, independent of its erythropoietic effects, during ischemic injury in non-anemic hosts. The goal of this study was to measure the cardioprotective effect of EPO compared to that of RBC transfusion in anemic rats after acute MI. Experimental Design: MI was induced by ligation of left descending coronary artery in 62 male Sprague-Dawley rats, 47 of which were anemic (Hb 80-90 g/L), and 15 with normal Hb levels (140-150 g/L). To compare the effects of EPO treatment and RBC transfusion (stored <4 hours in CPDA-1), animals were randomized and either treated with EPO (2,000 U/kg), transfused with RBC to a Hb level of 100 g/L, or received control treatment with saline instead of EPO, or pentastarch (PS) instead of transfusion, immediately following MI. Anemic and normal Hb animals were randomized into 6 treatment groups: 1. Normal Hb, saline treatment; 2. Normal Hb, EPO treatment; 3. Anemic, saline treatment; 4. Anemic, EPO treatment; 5. Anemic, PS infusion; 6. Anemic, transfusion to Hb 100 g/L. At 24 hours post-MI, hemodynamic measurements were obtained, and infarct size was determined. Results: Both normal Hb groups (EPO and saline treated) had significantly improved 24-hour survival compared to the anemic groups treated with saline and PS (100% and 90% vs. 54% and 50%, respectively; P<0.05). There was a non-significant trend of higher survival in anemic animals treated with EPO or transfusion (70% and 75%, respectively; P=NS) compared to the saline and PS groups. Twenty-four hours post-MI, the infarct size to area at risk ratios were significantly increased in the anemic saline and PS groups compared to the normal Hb group (P<0.05). Infarct size was significantly decreased in both the EPO treated and transfused groups compared to the anemic saline and PS groups (P<0.05). Cardiac function as measured by LVSP, dP/dtmax(contractility), and–dP/dtmin(diastolic function) was better preserved 24 hours post-MI in the normal Hb groups and the EPO or transfusion treated anemic animals compared to PS or saline treated anemic animals. No statistically significant differences were observed in infarct size or cardiac function between the EPO and transfusion treated anemic groups. Conclusions: EPO treatment was as effective as RBC transfusion in anemic animals after acute MI in reducing infarct size and improving cardiac function. The acute cardioprotective effects of EPO treatment occurred in the absence of any changes in Hb concentration. (This study was supported by the Canadian Institutes of Health Research, Canadian Blood Services, Bayer Partnership Fund, and the Anemia Institute of Research and Education). Disclosures: Xenocostas: Ortho Biotech, Canada: Consultancy, Honoraria, Research Funding.
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,001 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,001 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».