Endoscopic ultrasound features of pancreatic schwannoma
Notice bibliographique
Résumé
A 59-year-old female underwent abdominal ultrasound for dyspepsia. A 2 cm pancreatic nodule was incidentally discovered. Computer tomography scanning confirmed a solid mass of the pancreatic uncinate process; at endoscopic ultrasound (EUS) examination, it appeared as a round, well-demarked, solid homogeneous, hypoechoic mass [Figure 1]. In contrast-enhanced EUS (CE-EUS) images, the lesion showed poor contrast intake, with a hypoenhanced pattern compared to the surrounding pancreatic parenchyma [Figure 2]. Fine-needle aspiration (FNA) with a standard 25G needle revealed spindle cells [Figure 3] that expressed S-100 protein, suggestive for schwannoma. Surgical enucleation was performed, and diagnosis was confirmed on a surgical specimen [Figure 4].Figure 1: Linear endoscopic ultrasound demonstrating a solid, homogeneous, well-defined hypoechoic lesion in the uncinate process of the pancreasFigure 2: Contrast-enhanced endoscopic ultrasound showing a hypoenhanced pattern of the tumor compared with the surrounding pancreatic parenchymaFigure 3: Endoscopic ultrasound-guided fine-needle aspiration specimen showing dense fibrillary substance with Antoni A palisading spindle-shaped cells (Papanicolaou, ×40)Figure 4: Surgical specimen histopathology: Solid nodular lesion, surrounded by a fibrous capsule (a), in which the typical hallmark of a schwannoma growth pattern of alternating Antoni A and B areas is clearly visible (b) (EE, ×10). S-100 protein is strongly expressed by schwannoma cells (c)Pancreatic schwannoma is an extremely rare tumor. Complete descriptions of the EUS features or exhaustive EUS images are found in five reports[12345] whereas the CE-EUS pattern is described in a single one[5] [Table 1].Table 1: Main endoscopic ultrasound features of reported pancreatic schwannomasSchwannomas are capsulated tumors that, at imaging, are generally round or oval and show well-defined margins. Histologically, schwannomas comprised two areas: Antoni A, characterized by packed spindle cells and a vascular component, and Antoni B, which is hypocellular and occupied by loose stroma. The latter area may be the subject of degenerative changes, such as cyst formation, hemorrhage, necrosis, and calcification. Cystic degeneration is related to larger sizes and can affect the endosonographic appearance. When it is small (generally <2 cm), schwannoma can appear as a solid homogeneous lesion.[24] The vascular component of the Antoni A area is likely responsible for the poor contrast intake. In our case, as reported by Nishikawa et al.,[5] the lesion was hypoenhanced, compared to the surrounding pancreatic parenchyma; this feature is common to the pancreatic carcinoma from which schwannoma differs in the well-defined margins and the noninfiltrative behavior. Larger schwannomas with cystic changes mimic the whole spectrum of cystic pancreatic lesions. The preoperative diagnosis of cystic neuroendocrine tumor and of solid pseudopapillary neoplasm may be difficult. The hypoenhanced pattern of schwannoma at CE-EUS may help achieve the diagnosis. Targeting the solid component during FNA is mandatory. Financial support and sponsorship Nil. Conflicts of interest There are no conflicts of interest.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».