Endoscopic ultrasound features of pancreatic schwannoma
Bibliographic record
Abstract
A 59-year-old female underwent abdominal ultrasound for dyspepsia. A 2 cm pancreatic nodule was incidentally discovered. Computer tomography scanning confirmed a solid mass of the pancreatic uncinate process; at endoscopic ultrasound (EUS) examination, it appeared as a round, well-demarked, solid homogeneous, hypoechoic mass [Figure 1]. In contrast-enhanced EUS (CE-EUS) images, the lesion showed poor contrast intake, with a hypoenhanced pattern compared to the surrounding pancreatic parenchyma [Figure 2]. Fine-needle aspiration (FNA) with a standard 25G needle revealed spindle cells [Figure 3] that expressed S-100 protein, suggestive for schwannoma. Surgical enucleation was performed, and diagnosis was confirmed on a surgical specimen [Figure 4].Figure 1: Linear endoscopic ultrasound demonstrating a solid, homogeneous, well-defined hypoechoic lesion in the uncinate process of the pancreasFigure 2: Contrast-enhanced endoscopic ultrasound showing a hypoenhanced pattern of the tumor compared with the surrounding pancreatic parenchymaFigure 3: Endoscopic ultrasound-guided fine-needle aspiration specimen showing dense fibrillary substance with Antoni A palisading spindle-shaped cells (Papanicolaou, ×40)Figure 4: Surgical specimen histopathology: Solid nodular lesion, surrounded by a fibrous capsule (a), in which the typical hallmark of a schwannoma growth pattern of alternating Antoni A and B areas is clearly visible (b) (EE, ×10). S-100 protein is strongly expressed by schwannoma cells (c)Pancreatic schwannoma is an extremely rare tumor. Complete descriptions of the EUS features or exhaustive EUS images are found in five reports[12345] whereas the CE-EUS pattern is described in a single one[5] [Table 1].Table 1: Main endoscopic ultrasound features of reported pancreatic schwannomasSchwannomas are capsulated tumors that, at imaging, are generally round or oval and show well-defined margins. Histologically, schwannomas comprised two areas: Antoni A, characterized by packed spindle cells and a vascular component, and Antoni B, which is hypocellular and occupied by loose stroma. The latter area may be the subject of degenerative changes, such as cyst formation, hemorrhage, necrosis, and calcification. Cystic degeneration is related to larger sizes and can affect the endosonographic appearance. When it is small (generally <2 cm), schwannoma can appear as a solid homogeneous lesion.[24] The vascular component of the Antoni A area is likely responsible for the poor contrast intake. In our case, as reported by Nishikawa et al.,[5] the lesion was hypoenhanced, compared to the surrounding pancreatic parenchyma; this feature is common to the pancreatic carcinoma from which schwannoma differs in the well-defined margins and the noninfiltrative behavior. Larger schwannomas with cystic changes mimic the whole spectrum of cystic pancreatic lesions. The preoperative diagnosis of cystic neuroendocrine tumor and of solid pseudopapillary neoplasm may be difficult. The hypoenhanced pattern of schwannoma at CE-EUS may help achieve the diagnosis. Targeting the solid component during FNA is mandatory. Financial support and sponsorship Nil. Conflicts of interest There are no conflicts of interest.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".