P284 Ulcerative colitis – presentation during pregnancy or puerperium
Notice bibliographique
Résumé
Background: Even though ulcerative colitis (UC) frequently affects young women in reproductive age, it is rare to observe its first presentation during pregnancy. The aim of this study was to assess the characteristics and natural history of UC in patients who had their first presentation during pregnancy or puerperium. Methods: We performed a retrospective unicentre case-control study, with inclusion of UC patients whose diagnosis was made during pregnancy or in the post-partum period. We used 44 women whose diagnosis was made during reproductive age but without any relationship to pregnancy as a control group (mean age at diagnosis 28±6.6 years). Demographic, clinical and treatment data was collected through access to electronical medical records. Statistical analysis was performed with SPSS® 20.0. Results: We included as cases 9 women with a mean age at diagnosis of 28±4.7 years (range: 16.7–37.2 years). Concerning extension according to Montreal classification, 1 patient (11.1%) had proctitis, 2 patients (22.2%) distal colitis and 6 patients (66.7%) extensive colitis. Three cases occurred in former smokers but in only 2 the cessation of smoking occurred in the months previous to diagnosis. There was a statistically significant difference regarding smoking status between cases and controls (smokers/former smokers: 50% in cases vs 11.9% in controls; p=0.05). Even though the differences weren't statistically significant, we observed a greater proportion of extensive colitis in cases comparatively to controls [66.7% vs 36.4%, p=non-significant (NS)]. Cases also had a greater need of corticosteroids at diagnosis, even after adjustment for confounding variables (OR 6.3; IC95% 1.1–35.9; p=0.04), which may indicate a greater severity of the disease at presentation. However, we found no differences between cases and controls in the need of corticosteroids (77.8% vs 50%, p=NS), immunomodulators (11.1% vs 15.9%, p=NS) or biologic treatment (22.2% vs 11.4%, p=NS) during follow up. Conclusions: Smoking status, namely smoking cessation, appears to have a relationship with the risk of presentation of UC during pregnancy or puerperium, which is in agreement with the known relationship of tobacco and UC described in the literature. Even though the presentation of the disease in this period appears to be more severe, this doesn't seem to affect its natural history, as represented by the need of a more aggressive treatment.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».