P284 Ulcerative colitis – presentation during pregnancy or puerperium
Bibliographic record
Abstract
Background: Even though ulcerative colitis (UC) frequently affects young women in reproductive age, it is rare to observe its first presentation during pregnancy. The aim of this study was to assess the characteristics and natural history of UC in patients who had their first presentation during pregnancy or puerperium. Methods: We performed a retrospective unicentre case-control study, with inclusion of UC patients whose diagnosis was made during pregnancy or in the post-partum period. We used 44 women whose diagnosis was made during reproductive age but without any relationship to pregnancy as a control group (mean age at diagnosis 28±6.6 years). Demographic, clinical and treatment data was collected through access to electronical medical records. Statistical analysis was performed with SPSS® 20.0. Results: We included as cases 9 women with a mean age at diagnosis of 28±4.7 years (range: 16.7–37.2 years). Concerning extension according to Montreal classification, 1 patient (11.1%) had proctitis, 2 patients (22.2%) distal colitis and 6 patients (66.7%) extensive colitis. Three cases occurred in former smokers but in only 2 the cessation of smoking occurred in the months previous to diagnosis. There was a statistically significant difference regarding smoking status between cases and controls (smokers/former smokers: 50% in cases vs 11.9% in controls; p=0.05). Even though the differences weren't statistically significant, we observed a greater proportion of extensive colitis in cases comparatively to controls [66.7% vs 36.4%, p=non-significant (NS)]. Cases also had a greater need of corticosteroids at diagnosis, even after adjustment for confounding variables (OR 6.3; IC95% 1.1–35.9; p=0.04), which may indicate a greater severity of the disease at presentation. However, we found no differences between cases and controls in the need of corticosteroids (77.8% vs 50%, p=NS), immunomodulators (11.1% vs 15.9%, p=NS) or biologic treatment (22.2% vs 11.4%, p=NS) during follow up. Conclusions: Smoking status, namely smoking cessation, appears to have a relationship with the risk of presentation of UC during pregnancy or puerperium, which is in agreement with the known relationship of tobacco and UC described in the literature. Even though the presentation of the disease in this period appears to be more severe, this doesn't seem to affect its natural history, as represented by the need of a more aggressive treatment.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".