N817 Epidemiological profile of Crohn's disease and ulcerative colitis in a Brazilian single centre
Notice bibliographique
Résumé
Background: Epidemiological studies of Inflammatory Bowel Disease (IBD) are scarce in Latin America. The purpose of this study was to evaluate the demographic characteristics and clinical aspects of Crohn's Disease (CD) and Ulcerative Colitis (UC) in a single centre in Brazil. Methods: Retrospective study. Epidemiological and clinical data were extracted from the hospital database containing 136 patients with IBD that live on the Midwestern of Sao Paulo state. The data were collected between January and November 2016 and included all patients with 15 years old or over with CD or UC confirmed. This study was approved by the Research Ethics Committee (CAAE: 50640915.2.0000.5411). Results: Sixty-two patients with CD and 74 patients with UC were evaluated. Among patients with CD, 54.83% female, 90.32% declared Caucasian ethnicity and mean age was 44.58 years (±15.7). Seven patients were smokers (11.29%). The average disease duration was 13.8y (±8.9). By Montreal Classification, the patients were classified as A1 (≤16 years): 8.06%, A2 (17–40 years): 67.74% and A3 (>40 years): 19.35%; L1 (Terminal ileum): 25.80%, L2 (Colonic): 11.29%, L3 (Ileocolonic): 58.06% and L4 (Isolated upper GI disease): 3.22%; B1 (Nonstricturing, nonpenetrating): 11.29%, B2 (Stricturing): 46.77% and B3 (Penetrating): 35.48%. Any stage of perianal disease was found in 50% of patients. Presence of complications was frequently found in the sample, specially intestinal stenosis (33.87%), fistulae (29.03%) and abscess (12.90%). The most frequent extra-intestinal manifestations were arthralgia (19.35%) and erythema nodosum (9.67%). Primary sclerosing cholangitis (PSC) was described in 3.22% of the patients. About treatment, 74.19% use Azathioprine; 19.35% Mesalazine; 32.25% Infliximab and 24.19% Adalimumab. The use of corticosteroids has been reported in 37.09%. With UC, 74 patients were reported, totalizing 64.86% female, the mean age was 50.1y (±17.7), 9.45% smokers. The average of disease duration was 14.4y (±10.1). Location data included 50.05% of the patients with pancolitis, 16.21% with left colitis, and 20.27% with distal colitis. Arthralgia was presented in 23%, sacroileitis in 4.05% and PSC in 2.70%. One patient developed colorectal cancer. The treatment consisted in oral Mesalazine in 55.40%, Sulfasalazine in 28.37% and Mesalazine suppository in 21.62%. Azathioprine has been used in 35.13% and 3 patients used biological therapy (2 with Infliximab and 1 with Adalimumab). Conclusions: In this study, there was a small predominance of patients with UC. Females were more prevalent in both diseases. Stenosis, fistulae and abscess were the most common complications on CD patients. For UC, pancolitis was the principal disease location.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,003 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,002 | 0,002 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,000 | 0,001 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».