N817 Epidemiological profile of Crohn's disease and ulcerative colitis in a Brazilian single centre
Bibliographic record
Abstract
Background: Epidemiological studies of Inflammatory Bowel Disease (IBD) are scarce in Latin America. The purpose of this study was to evaluate the demographic characteristics and clinical aspects of Crohn's Disease (CD) and Ulcerative Colitis (UC) in a single centre in Brazil. Methods: Retrospective study. Epidemiological and clinical data were extracted from the hospital database containing 136 patients with IBD that live on the Midwestern of Sao Paulo state. The data were collected between January and November 2016 and included all patients with 15 years old or over with CD or UC confirmed. This study was approved by the Research Ethics Committee (CAAE: 50640915.2.0000.5411). Results: Sixty-two patients with CD and 74 patients with UC were evaluated. Among patients with CD, 54.83% female, 90.32% declared Caucasian ethnicity and mean age was 44.58 years (±15.7). Seven patients were smokers (11.29%). The average disease duration was 13.8y (±8.9). By Montreal Classification, the patients were classified as A1 (≤16 years): 8.06%, A2 (17–40 years): 67.74% and A3 (>40 years): 19.35%; L1 (Terminal ileum): 25.80%, L2 (Colonic): 11.29%, L3 (Ileocolonic): 58.06% and L4 (Isolated upper GI disease): 3.22%; B1 (Nonstricturing, nonpenetrating): 11.29%, B2 (Stricturing): 46.77% and B3 (Penetrating): 35.48%. Any stage of perianal disease was found in 50% of patients. Presence of complications was frequently found in the sample, specially intestinal stenosis (33.87%), fistulae (29.03%) and abscess (12.90%). The most frequent extra-intestinal manifestations were arthralgia (19.35%) and erythema nodosum (9.67%). Primary sclerosing cholangitis (PSC) was described in 3.22% of the patients. About treatment, 74.19% use Azathioprine; 19.35% Mesalazine; 32.25% Infliximab and 24.19% Adalimumab. The use of corticosteroids has been reported in 37.09%. With UC, 74 patients were reported, totalizing 64.86% female, the mean age was 50.1y (±17.7), 9.45% smokers. The average of disease duration was 14.4y (±10.1). Location data included 50.05% of the patients with pancolitis, 16.21% with left colitis, and 20.27% with distal colitis. Arthralgia was presented in 23%, sacroileitis in 4.05% and PSC in 2.70%. One patient developed colorectal cancer. The treatment consisted in oral Mesalazine in 55.40%, Sulfasalazine in 28.37% and Mesalazine suppository in 21.62%. Azathioprine has been used in 35.13% and 3 patients used biological therapy (2 with Infliximab and 1 with Adalimumab). Conclusions: In this study, there was a small predominance of patients with UC. Females were more prevalent in both diseases. Stenosis, fistulae and abscess were the most common complications on CD patients. For UC, pancolitis was the principal disease location.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".