P504 Differences between paediatric and adult inflammatory bowel disease presentation – analysis based on the data from multicenter, prospective cohort observational study assessing safety of anti-TNF therapy – Satimos study
Notice bibliographique
Résumé
Background: Anti-TNF therapy is actually easy available for inflammatory bowel disease treatment. Even if biologics are commonly used for many years, surveillance, especially focusing at safety is needed. In that case, study to assess efficacy and prevalence of adverse events in Polish cohort adult and pediatric patients with Crohn's disease (CD) and ulcerative colitis (UC) has been started. In database were recorded information about demographic and medical history. The aim of actual assessment was to compare disease presentation between children and adults with inflammatory bowel disease qualified to anti-TNF therapy. Methods: A multicenter, prospective cohort observational study was started at January 2014. To study were included all patients in every age who started anti-TNF treatment. From final assessment were excluded 74 patient due to lack of complete data. Data were recorded with use of electronical database. Demographical findings, collateral diseases, history of treatment were also collected. Finally, 667 patients were enrolled to the study. Group consist 397 adults (59.6%) and 270 patients aged below 18 years old (40.4%). Results: Time from first symptoms to diagnosis varied between type of disease and age. Diagnosis was performed earlier for patients aged below 18 years. Mean time was 4 months for UC and 6.9 months for CD in pediatric population vs 7.8 months and 12 months in adults, respectively. At the moment of anti-TNF qualification, most UC patients presented high disease severity. 58,0% adults and 60.4% children were definied as E3 in Montreal classification. Among CD patients the most common disease localisation in children were colon (40.2%) and terminal ileum (38.3%) meanwhile terminal ileum in adults were affected only in 29.3%. The most common disease localisation in adults were large intestine (44.3%). Upper digestive tract were 4 times more common affected in children 27.1%; vs 7.2% in adults. Most patients were qualified to biological treatment due to luminal active disease. Nevertheless, young patients with CD earlier than adults needed biological therapy. Mean time from diagnosis to treatment with biologic therapy was 1.4 years for children with CD, and 5.8 years for adults. Mean time among UC patients were 2.0 years for children and 4.3 years for adults. Conclusions: Analysis showed that pediatric patients mostly have more aggressive form of disease what lead to earlier disease diagnosis and earlier need of anti-TNF treatment. In comparison to adults, in children with CD, localisation is more common in terminal ileum and upper digestive track.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,002 | 0,005 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,001 |
| Bibliométrie | 0,001 | 0,002 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,000 | 0,001 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,003 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».