P504 Differences between paediatric and adult inflammatory bowel disease presentation – analysis based on the data from multicenter, prospective cohort observational study assessing safety of anti-TNF therapy – Satimos study
Bibliographic record
Abstract
Background: Anti-TNF therapy is actually easy available for inflammatory bowel disease treatment. Even if biologics are commonly used for many years, surveillance, especially focusing at safety is needed. In that case, study to assess efficacy and prevalence of adverse events in Polish cohort adult and pediatric patients with Crohn's disease (CD) and ulcerative colitis (UC) has been started. In database were recorded information about demographic and medical history. The aim of actual assessment was to compare disease presentation between children and adults with inflammatory bowel disease qualified to anti-TNF therapy. Methods: A multicenter, prospective cohort observational study was started at January 2014. To study were included all patients in every age who started anti-TNF treatment. From final assessment were excluded 74 patient due to lack of complete data. Data were recorded with use of electronical database. Demographical findings, collateral diseases, history of treatment were also collected. Finally, 667 patients were enrolled to the study. Group consist 397 adults (59.6%) and 270 patients aged below 18 years old (40.4%). Results: Time from first symptoms to diagnosis varied between type of disease and age. Diagnosis was performed earlier for patients aged below 18 years. Mean time was 4 months for UC and 6.9 months for CD in pediatric population vs 7.8 months and 12 months in adults, respectively. At the moment of anti-TNF qualification, most UC patients presented high disease severity. 58,0% adults and 60.4% children were definied as E3 in Montreal classification. Among CD patients the most common disease localisation in children were colon (40.2%) and terminal ileum (38.3%) meanwhile terminal ileum in adults were affected only in 29.3%. The most common disease localisation in adults were large intestine (44.3%). Upper digestive tract were 4 times more common affected in children 27.1%; vs 7.2% in adults. Most patients were qualified to biological treatment due to luminal active disease. Nevertheless, young patients with CD earlier than adults needed biological therapy. Mean time from diagnosis to treatment with biologic therapy was 1.4 years for children with CD, and 5.8 years for adults. Mean time among UC patients were 2.0 years for children and 4.3 years for adults. Conclusions: Analysis showed that pediatric patients mostly have more aggressive form of disease what lead to earlier disease diagnosis and earlier need of anti-TNF treatment. In comparison to adults, in children with CD, localisation is more common in terminal ileum and upper digestive track.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.005 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".