20. Metabolic Abnormalities and Omega-3 Fatty Acids in Latinos at Clinical High Risk for Psychosis
Notice bibliographique
Résumé
Background: Previous work has established a relationship between metabolic abnormalities and poorer health outcomes in individuals with schizophrenia spectrum disorders. It is likely that metabolic abnormalities, inflammation, and oxidative stress observed in individuals with schizophrenia actually begin to occur prior to the onset of psychosis and may potentially serve as a risk factor in populations at clinical high risk for developing psychosis. Further, in the general population, it has been established that Latino individuals have a higher incidence of metabolic abnormalities than non-Latinos, making CHR Latinos especially vulnerable to the compounded effects of pre-existing metabolic disturbances with added risk of further metabolic disturbance associated with the development of psychosis. In a Clinical Trial of Omega 3 Fatty Acid versus Placebo, baseline cardiometabolic and oxidative stress indices were investigated in a group at Clinical High Risk (CHR) for psychosis from the North American Prodromal Longitudinal Studies (NAPLS). The goal of the present report was to compare cardiometabolic indices in Latino versus non-Latino CHR subjects. Methods: Subjects met CHR criteria per the Structured Interview of Prodromal Syndromes (SIPS), received physical exams and metabolic monitoring prior to randomization into the Omega 3 trial. Antipsychotic medication or history of diabetes were exclusions. Anthropometrical measures, vital signs, glucose, and lipids were assessed. RBC fatty acid composition was analyzed as a measure of dietary Omega-3. Results: The sample included 127 CHR subjects (57.9% male) ages 12–30 (Mean/SD = 18.5/4.6). Latino individuals comprise 82.5% of the sample and 66.7% of the subjects were white. Racial and ethnic groups did not differ significantly by age, sex, smoking history or antipsychotic exposure at baseline. Latinos subjects were more likely to have metabolic syndrome (F = 3.6, P = .016), higher levels of serum glucose (F = 7.7, P = .007), larger abdominal obesity (F= 9.29, P = .003), and have dyslipidemia (F = 4.23, P = .043). Latino subjects had significantly lower omega 3/6 ratio trans (F = 9.12, P = .003) and omega 3/6 ratio nontrans (F = 9.12, P = .003). Conclusion: Significant differences were found between Latino and non-Latino CHR individuals, suggesting Latinos were more likely to suffer from metabolic abnormalities. These abnormalities were significantly associated with greater clinical symptoms and worse functional outcomes. Latino CHR individuals are a vulnerable minority that may suffer greater clinical and functional impairment. Special considerations should be given to this group especially if it is identified that metabolic disturbances are predictive of transition to psychosis.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,002 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,001 | 0,001 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,001 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».