Prescription medicine use by one million Canadian children
Pourquoi ce travail est dans la base
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Notice bibliographique
Résumé
Drugs are an increasing and integral part of the treatment of childhood conditions. There is widespread concern regarding the inadequacy of paediatric data from clinical trials, which results in limited prescribing information available to support optimal pharmacotherapy for children. One explanation for the limited prescribing information in paediatrics is the perception of relatively infrequent use of drugs in the treatment of childhood conditions. To date there have been few population studies quantifying the extent of prescription drug use among Canadian children. Prescription information from administrative databases were available for over one million paediatric claimants likely representing approximately two million eligible children. Nearly 15% of Canadian children actually had a claim for a prescription drug recorded in this database. Descriptive statistics were employed to describe drug utilization for those who had a drug claim. The two largest therapeutic areas were antibiotics (76% of claimants) and respiratory drugs (18% of claimants). Among the top 20 drugs dispensed to paediatric claimants, 14 were antibiotics and the top drug overall was amoxicillin. Psychotropic drugs defined as stimulants, antidepressants, antipsychotics and anticonvulsants were dispensed to 6% of all paediatric claimants. In virtually every therapeutic area, the usage of drugs differed markedly across age groups. A wide range of drugs are prescribed to children, many of which are being used outside of the age ranges approved by Health Canada. However, most new drugs are used relatively infrequently in children. The large numbers of Canadian children documented in this study using prescription medicines reinforces the value of vigilance in ensuring that physicians are equipped with adequate information to ensure safe and effective prescribing. The use of therapeutic drugs is widespread, and for a large number of these drugs, safety and efficacy among children has not been established, although no conclusions can be drawn from this study about appropriateness of drug therapy in children. Consequently, ongoing vigilance in accurate paediatric labelling as well as future pharmacoepidemiologic studies addressing safety and efficacy are required. Efforts must be concentrated on those specific age ranges in which products or drug classes are used, evidence of which can be determined from actual utilization.
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Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découle