A337 RESULTS OF PILOT HEPATITIS C SCREENING PROGRAM IN INFANTS BORN TO HIGH RISK MOTHERS
Notice bibliographique
Résumé
Hepatitis C (HCV) is a global health concern with an estimated 2–3 % of the general population infected. It is estimated that the vertical transmission rate of mother-to-child is 5.8%. Due to the placental transfer of maternal antibodies, confirmation of hepatitis C infection is often delayed until the baby is 12–18 months of age, however many centres across North America screen earlier in order to ensure screening. There are limited centres in Canada with a formal infant screening program and limited data regarding the rate of HCV transmission. Many primary care physicians and pediatricians do not have the awareness of when to implement a screening initiative for these at-risk babies. Identifiable factors in addition to maternal HCV-positive serostatus include illicit drug use and peri-natal methadone maintanence therapy (MMT) which is common in our community yet we do not screen mother nor babies. 1. Does a formal targeted program improve screening and identify children with HCV?. 2. What is the mother-to-child transmission rate observed in our community?. 3. What are the barriers to screening? At risk mothers (HCV positive, on MMT, confirmed/suspected illicit drug use) are identified at the time of delivery and a referral for follow-up sent to both the research team primary care provider explaining the need and timing for screening and the details around data collection for the purposes of this study. The family doctor or research team then contacts the family to arrange screening. Patient results and/or reasons for not screening are documented and monitored. A total of 26 infants were included in the pilot program conducted between January 2015 and February 2016. Babies were screened at an average of 10.8 months (range 1.7–17.9 months). Of the mothers, 11/27 (42.3%) were HCV positive, the remaining 15 (57.7%) infants had mothers with other high risk behaviours for HCV acquisition but an unknown HCV status. Six (23.1%) of babies have been screened for HCV as of October 12, 2016. All were found to be negative. There remains a lack of data regarding the vertical transmission rate and outcome of infant HCV in Canada. There are many barriers to screening including patients lost to follow-up and screening refusal due to venipuncture. A longer prospective study is now underway to look for patient friendly alternatives to screening including point of care buccal swab tests being used in other countries. We also hope to follow patients once they are identified to be HCV positive in order to document clearance rates and/or possible treatment success. Also an infant screening program will serve to educate those on the importance of identifying HCV in pregnant mothers since treatment of the mother following delivery is safe and well tolerated. None
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,004 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,003 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».