A337 RESULTS OF PILOT HEPATITIS C SCREENING PROGRAM IN INFANTS BORN TO HIGH RISK MOTHERS
Bibliographic record
Abstract
Hepatitis C (HCV) is a global health concern with an estimated 2–3 % of the general population infected. It is estimated that the vertical transmission rate of mother-to-child is 5.8%. Due to the placental transfer of maternal antibodies, confirmation of hepatitis C infection is often delayed until the baby is 12–18 months of age, however many centres across North America screen earlier in order to ensure screening. There are limited centres in Canada with a formal infant screening program and limited data regarding the rate of HCV transmission. Many primary care physicians and pediatricians do not have the awareness of when to implement a screening initiative for these at-risk babies. Identifiable factors in addition to maternal HCV-positive serostatus include illicit drug use and peri-natal methadone maintanence therapy (MMT) which is common in our community yet we do not screen mother nor babies. 1. Does a formal targeted program improve screening and identify children with HCV?. 2. What is the mother-to-child transmission rate observed in our community?. 3. What are the barriers to screening? At risk mothers (HCV positive, on MMT, confirmed/suspected illicit drug use) are identified at the time of delivery and a referral for follow-up sent to both the research team primary care provider explaining the need and timing for screening and the details around data collection for the purposes of this study. The family doctor or research team then contacts the family to arrange screening. Patient results and/or reasons for not screening are documented and monitored. A total of 26 infants were included in the pilot program conducted between January 2015 and February 2016. Babies were screened at an average of 10.8 months (range 1.7–17.9 months). Of the mothers, 11/27 (42.3%) were HCV positive, the remaining 15 (57.7%) infants had mothers with other high risk behaviours for HCV acquisition but an unknown HCV status. Six (23.1%) of babies have been screened for HCV as of October 12, 2016. All were found to be negative. There remains a lack of data regarding the vertical transmission rate and outcome of infant HCV in Canada. There are many barriers to screening including patients lost to follow-up and screening refusal due to venipuncture. A longer prospective study is now underway to look for patient friendly alternatives to screening including point of care buccal swab tests being used in other countries. We also hope to follow patients once they are identified to be HCV positive in order to document clearance rates and/or possible treatment success. Also an infant screening program will serve to educate those on the importance of identifying HCV in pregnant mothers since treatment of the mother following delivery is safe and well tolerated. None
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.004 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".