A296 A RHYTHMIC MOTOR PATTERN ASSOCIATED WITH HIGH AMPLITUDE PRESSURE WAVES IN HUMAN HIGH-RESOLUTION COLONIC MANOMETRY
Notice bibliographique
Résumé
High Amplitude Pressure Waves (HAPWs) are the only motor pattern routinely assessed in human colonic manometry. High-Resolution Colonic Manometry is able to provide more information and shows HAPW associated motor patterns that may have clinical relevance. Our aim was to characterize the HAPW associated rhythmic motor pattern, its myogenic basis based on its frequency pattern, its physiological significance and its potential diagnostic value. High-resolution manometry was performed using an 84 sensor water-perfused catheter in 7 healthy subjects. Pressures were recorded at baseline, after a meal, in response to balloon distension and bisacodyl administration. The most consistent motor pattern that followed HAPWs in healthy adults was a characteristic rhythmic motor pattern with distinct frequency components of 6, 9,12 and 15 cpm, clearly distinguishable from the breathing frequency. This pattern had an average duration of 78.1 ± 49.6 s (24 to 165), occurring over a section of the colon of 11.5 ± 5.9 cm (6 to18) length, which is about 2 or 3 haustra. The motor pattern ended 24.0 ± 7.0 cm above the anal verge; hence it is a characteristic of the sigmoid colon. Individual pressure transients within the pattern occurred almost exclusively instantaneous. To quantify, HAPWs were evoked by balloon distention, a 1000 kcal meal, and 10 mg luminal bisacodyl. Using balloon distention, 31 HAPWs were evoked, 16.1% were followed by quiescence and 48.4% by the rhythmic motor pattern; other HAPWs were associated with spontaneous pressure waves without the occurrence of this rhythmic motor pattern. In response to a meal, 30 HAPWs were evoked, 10.0 % were followed by quiescence and 33.3 % by the rhythmic motor pattern. In response to bisacodyl, 39 HAPWs were evoked, 5.1 % were followed by quiescence and 46.2 % by the rhythmic motor pattern. This motor pattern also occurred independently of the HAPWs with dominant frequencies of 3 and 6 cpm at baseline condition, indicating the motor pattern was in a less excited state with more retrograde propagation. A rhythmic motor pattern characteristically follows the HAPW in the sigmoid colon. Its occurrence after an HAPW suggests that this rhythmic motor pattern shares neural excitation with the HAPWs. Its frequency spectrum (3,6,9,12,15 cpm) and very fast propagation (or instantaneous appearance) suggest orchestration by a network of interstitial cells of Cajal (ICC). The frequency spectrum is identical to that in previous electrical recordings of the human colon (2). The occurrence of this motor pattern in healthy adults suggests that it may not be a biomarker of constipation in adults (1) and suggests that it may be a signature of intrinsic ICC activity. 1. Giorgio et al. Neurogastr. Mot. 2013. 2. Sarna et al. Gastroenterology 1981. High-Resolution Colonic Manometry: a High Amplitude Pressure Wave is followed by a Rhythmic Motor Pattern in the distal colon. CIHRHamilton Academic Health Sciences Organization
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».