A296 A RHYTHMIC MOTOR PATTERN ASSOCIATED WITH HIGH AMPLITUDE PRESSURE WAVES IN HUMAN HIGH-RESOLUTION COLONIC MANOMETRY
Bibliographic record
Abstract
High Amplitude Pressure Waves (HAPWs) are the only motor pattern routinely assessed in human colonic manometry. High-Resolution Colonic Manometry is able to provide more information and shows HAPW associated motor patterns that may have clinical relevance. Our aim was to characterize the HAPW associated rhythmic motor pattern, its myogenic basis based on its frequency pattern, its physiological significance and its potential diagnostic value. High-resolution manometry was performed using an 84 sensor water-perfused catheter in 7 healthy subjects. Pressures were recorded at baseline, after a meal, in response to balloon distension and bisacodyl administration. The most consistent motor pattern that followed HAPWs in healthy adults was a characteristic rhythmic motor pattern with distinct frequency components of 6, 9,12 and 15 cpm, clearly distinguishable from the breathing frequency. This pattern had an average duration of 78.1 ± 49.6 s (24 to 165), occurring over a section of the colon of 11.5 ± 5.9 cm (6 to18) length, which is about 2 or 3 haustra. The motor pattern ended 24.0 ± 7.0 cm above the anal verge; hence it is a characteristic of the sigmoid colon. Individual pressure transients within the pattern occurred almost exclusively instantaneous. To quantify, HAPWs were evoked by balloon distention, a 1000 kcal meal, and 10 mg luminal bisacodyl. Using balloon distention, 31 HAPWs were evoked, 16.1% were followed by quiescence and 48.4% by the rhythmic motor pattern; other HAPWs were associated with spontaneous pressure waves without the occurrence of this rhythmic motor pattern. In response to a meal, 30 HAPWs were evoked, 10.0 % were followed by quiescence and 33.3 % by the rhythmic motor pattern. In response to bisacodyl, 39 HAPWs were evoked, 5.1 % were followed by quiescence and 46.2 % by the rhythmic motor pattern. This motor pattern also occurred independently of the HAPWs with dominant frequencies of 3 and 6 cpm at baseline condition, indicating the motor pattern was in a less excited state with more retrograde propagation. A rhythmic motor pattern characteristically follows the HAPW in the sigmoid colon. Its occurrence after an HAPW suggests that this rhythmic motor pattern shares neural excitation with the HAPWs. Its frequency spectrum (3,6,9,12,15 cpm) and very fast propagation (or instantaneous appearance) suggest orchestration by a network of interstitial cells of Cajal (ICC). The frequency spectrum is identical to that in previous electrical recordings of the human colon (2). The occurrence of this motor pattern in healthy adults suggests that it may not be a biomarker of constipation in adults (1) and suggests that it may be a signature of intrinsic ICC activity. 1. Giorgio et al. Neurogastr. Mot. 2013. 2. Sarna et al. Gastroenterology 1981. High-Resolution Colonic Manometry: a High Amplitude Pressure Wave is followed by a Rhythmic Motor Pattern in the distal colon. CIHRHamilton Academic Health Sciences Organization
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".