A326 HOSPITALIZATIONS FOR ACUTE AND CHRONIC PANCREATITIS IN A FRENCH-CANADIAN FOUNDER POPULATION
Notice bibliographique
Résumé
Acute pancreatitis (AP) is one of the most frequent gastrointestinal causes of hospitalization. Although less frequent, chronic pancreatitis (CP) also contributes to this burden. The severity, recurrence and risk trajectory (cancer, pancreas insufficiency) of pancreatitis vary among individuals. Heavy alcohol consumption or gallstones contribute to ~80% of all cases. Less frequent causes such as hereditary, idiopathic, autoimmune, metabolic or drug-induced, contribute less to the burden of hospitalizations but involve an important genetic component. The French Canadian founder population of the Saguenay-Lac-Saint-Jean (SLSJ) region (QC, Canada) is genetically less heterogeneous, which facilitates the identification of the genetic backbone of several diseases. This study is a component of a broader research program on the genetic dissection of the natural history of common and rare causes of pancreatitis, and aims to document the causes and relative burden of hospitalizations for AP and CP in the SLSJ population. This is a retrospective, population-based study of all hospitalizations for AP or CP in the SLSJ population between 2006 and 2014. Data were collected from the Quebec Ministry of Health hospitalizations registry (MED-ECHO). All pancreatitis events were reported according to the International Classification of Diseases-10 codes (CIM-10-CA). The analyzed data included diagnosis at discharge, age, sex and duration of stay. The yearly incidence of hospitalizations for AP and CP has been calculated and the Quebec registry on causes of deaths was used to estimate the pancreatitis-related mortality in the SLSJ region between 2000 and 2011. Overall, 93% of pancreatitis-related hospitalizations were for AP (n=1610) (mean age of 57 ± 19 years; men/women ratio of 1.08) and 7% for CP (n=118) (mean age of 53 ± 17 years; men/women ratio of 1.31). Inhospital length of stay (mean±SD) was 7 ± 10 days for AP and 7 ± 7 days for CP. During the studied period, 13% of hospitalizations for AP were related to alcohol, 21% to gallstones, 6% were idiopathic, 2% drug-induced and 58% were categorized as “undefined”. For CP, 31% were related to alcohol and 69% were undefined. The mean incidence of hospitalizations for AP or CP in the SLSJ was 148 cases yearly during the studied period. Also, there was a mean of four pancreatitis-related deaths yearly between 2000 and 2011 in this region. The burden of hospitalizations for AP was 13-fold that of CP. Altogether, alcohol and gallstones were associated with less than one third of hospitalizations for AP or CP during the studied period, suggesting that genetic factors may play a role in pancreatitis expression in this population. This is the case for severe hypertriglyceridemia due to lipoprotein lipase deficiency, a cause of recurrent AP which is 200-fold more prevalent in SLSJ than in the rest of the world. La Fondation de ma vie du Centre intégré universitaire de santé et de services sociaux du Saguenay-Lac-St-Jean
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,001 |
| Bibliométrie | 0,003 | 0,004 |
| Études des sciences et des technologies | 0,003 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,004 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».