A326 HOSPITALIZATIONS FOR ACUTE AND CHRONIC PANCREATITIS IN A FRENCH-CANADIAN FOUNDER POPULATION
Bibliographic record
Abstract
Acute pancreatitis (AP) is one of the most frequent gastrointestinal causes of hospitalization. Although less frequent, chronic pancreatitis (CP) also contributes to this burden. The severity, recurrence and risk trajectory (cancer, pancreas insufficiency) of pancreatitis vary among individuals. Heavy alcohol consumption or gallstones contribute to ~80% of all cases. Less frequent causes such as hereditary, idiopathic, autoimmune, metabolic or drug-induced, contribute less to the burden of hospitalizations but involve an important genetic component. The French Canadian founder population of the Saguenay-Lac-Saint-Jean (SLSJ) region (QC, Canada) is genetically less heterogeneous, which facilitates the identification of the genetic backbone of several diseases. This study is a component of a broader research program on the genetic dissection of the natural history of common and rare causes of pancreatitis, and aims to document the causes and relative burden of hospitalizations for AP and CP in the SLSJ population. This is a retrospective, population-based study of all hospitalizations for AP or CP in the SLSJ population between 2006 and 2014. Data were collected from the Quebec Ministry of Health hospitalizations registry (MED-ECHO). All pancreatitis events were reported according to the International Classification of Diseases-10 codes (CIM-10-CA). The analyzed data included diagnosis at discharge, age, sex and duration of stay. The yearly incidence of hospitalizations for AP and CP has been calculated and the Quebec registry on causes of deaths was used to estimate the pancreatitis-related mortality in the SLSJ region between 2000 and 2011. Overall, 93% of pancreatitis-related hospitalizations were for AP (n=1610) (mean age of 57 ± 19 years; men/women ratio of 1.08) and 7% for CP (n=118) (mean age of 53 ± 17 years; men/women ratio of 1.31). Inhospital length of stay (mean±SD) was 7 ± 10 days for AP and 7 ± 7 days for CP. During the studied period, 13% of hospitalizations for AP were related to alcohol, 21% to gallstones, 6% were idiopathic, 2% drug-induced and 58% were categorized as “undefined”. For CP, 31% were related to alcohol and 69% were undefined. The mean incidence of hospitalizations for AP or CP in the SLSJ was 148 cases yearly during the studied period. Also, there was a mean of four pancreatitis-related deaths yearly between 2000 and 2011 in this region. The burden of hospitalizations for AP was 13-fold that of CP. Altogether, alcohol and gallstones were associated with less than one third of hospitalizations for AP or CP during the studied period, suggesting that genetic factors may play a role in pancreatitis expression in this population. This is the case for severe hypertriglyceridemia due to lipoprotein lipase deficiency, a cause of recurrent AP which is 200-fold more prevalent in SLSJ than in the rest of the world. La Fondation de ma vie du Centre intégré universitaire de santé et de services sociaux du Saguenay-Lac-St-Jean
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.003 | 0.004 |
| Science and technology studies | 0.003 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".