A194 THE PREVALENCE OF SMALL INTESTINAL BACTERIAL OVERGROWTH IN PRIMARY BILIARY CHOLANGITIS
Notice bibliographique
Résumé
Primary Biliary Cholangitis (PBC) is a chronic autoimmune liver disease affecting mainly middle-aged women. An alteration of intestinal motility has been documented in cirrhosis due to alcohol or viruses, predisposing to small intestinal bacterial overgrowth (SIBO). SIBO is a condition in which colonic bacteria are seen in excess in the small intestine causing inflammation and malabsorption. No study has been published to determine the occurrence of SIBO in PBC that is distinguished from other cirrhosis by its autoimmune origin. Patients with PBC frequently complain of various gastrointestinal symptoms such as abdominal pain, bloating and diarrhea. We hypothesize that the prevalence of SIBO is high in PBC. This could be the cause of the numerous gastrointestinal symptoms reported by these patients. To determine the prevalence of SIBO in patients with PBC and to identify the characteristics associated with SIBO. Retrospective study at the CHUM Hospital (Montreal, Quebec, Canada) from 2010 to 2018. All patients diagnosed with PBC during the study period had a systematic screening for SIBO in their diagnostic workup. The diagnosis of SIBO was made by a carbohydrate breath test (lactulose and/or glucose at the physician’s discretion). Clinical and paraclinical factors were entered into a database and compared to a group of healthy subjects. That group of healthy subjects was a historical cohort of the gastrointestinal motor function laboratory that established the standards and validation of the breath tests. 102 patients were included in the study (mean age 51, range 20–82 years) including 62 patients with PBC and 40 healthy subjects. PBC patients were older than the healthy subjects (59, range 20–82 versus 39, range 21–62 years; p<0.05), but identical for gender and body mass index (BMI). The prevalence of SIBO was higher in PBC versus healthy subjects (29% versus 2.5%; p<0.001). Among patients with PBC, the clinical and paraclinical factors were similar in those with or without SIBO: age, gender, BMI, comorbidities, severity of cirrhosis. PBC patients with SIBO had significantly more abdominal pain (61.1% versus 31.8%; p<0.05) and diarrhea (83.3% versus 31.8%; p<0.001) than patients without SIBO, but the prevalence of bloating was similar (66.7% versus 68.2%; NS). The high occurrence of SIBO in PBC patients may explain the frequently reported gastrointestinal symptoms. None
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».