148. SHORT-FORM 36 AS A MEASURE OF HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH GIANT CELL ARTERITIS
Notice bibliographique
Résumé
Background: To evaluate the health-related quality of life (HRQoL) in patients with giant cell arteritis (GCA) as measured by the Short Form Health Survey (SF-36). Methods: Data from the first visit of patients with GCA enrolled in a multicenter, longitudinal cohort and/or a clinical trial were included. Subjects were followed with standardized clinical assessments including symptoms attributed to vasculitis, physician global assessment of disease activity (0-10 with 0 signifying remission), the Vasculitis Damage Index (VDI), and SF-36. Physical component scores (PCS) and mental component scores (MCS) were calculated from SF-36 and normalized to the general population (mean ± SD = 50 ± 10) with lower scores indicating poorer HRQoL. The domains of Physical Function (PF), Role Physical (RP), Bodily Pain (BP), General Health perceptions (GH), Vitality (VT), Social Functioning (SF), Role Emotional (RE), Mental Health index (MH) were also evaluated. Results: The study included 304 patients; 220 (72%) women; mean age at diagnosis = 71.3±8.5 years; 58% enrolled within 12 weeks of diagnosis. Temporal artery biopsy was positive in 165/205 (81%) patients. Visual manifestations were present in 38%, upper extremity claudication in 18%, and lower extremity claudication in 6%. Disease was characterized as being in remission in 57% of patients. At least one damage item was present in 58%. Mean±SD PCS (39.7±11.5) and MCS (47.2±12.8) were statistically lower in patients with GCA compared to the general population, p < 0.01. PCS were lower in females (37.8 vs 43.3 in males, p < 0.01), patients with any damage item on VDI (38.0 vs 41.3 in patients with VDI=0, p 0.02) and patients with active disease (37.7 vs 41.3 in remission, p 0.01). Mean MCS was lower in patients with active disease (45.7 vs 48.8 in remission, p 0.04). There were no differences in PCS or MCS in patients with i) recently diagnosed disease, ii) with/without vision loss, iii) with/without upper or lower extremity claudication (p > 0.05). Domains of PF and BP were statistically lower in females, patients with damage had lower PF scores. Patients with active disease had lower RP, BP, VT, SF and MH scores Figure 1. SF-36 scores among patients with giant cell arteritis. Left panel: Differences in physical component score (PCS) and mental component score (MCS) in patients with active and inactive disease (solid line represents the general population). Right panel: Differences in domains of Physical Function (PF), Role Physical (RP), Bodily Pain (BP), General Health perceptions (GH), Vitality (VT), Social Functioning (SF), Role Emotional (RE), and Mental Health index (MH) in patients with giant cell arteritis based on presence or absence of active disease, and compared to the general population (GP). Conclusion: Patients with GCA have reduced HRQoL, as measured by the SF-36. While SF-36 appears sensitive to disease activity, it did not differ in patients with serious manifestations such as vision loss or limb claudication which would be expected to impact quality of life. Disease-specific measures may better capture the burden of disease from the patient’s perspective in GCA.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,003 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,001 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,003 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».