148. SHORT-FORM 36 AS A MEASURE OF HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH GIANT CELL ARTERITIS
Bibliographic record
Abstract
Background: To evaluate the health-related quality of life (HRQoL) in patients with giant cell arteritis (GCA) as measured by the Short Form Health Survey (SF-36). Methods: Data from the first visit of patients with GCA enrolled in a multicenter, longitudinal cohort and/or a clinical trial were included. Subjects were followed with standardized clinical assessments including symptoms attributed to vasculitis, physician global assessment of disease activity (0-10 with 0 signifying remission), the Vasculitis Damage Index (VDI), and SF-36. Physical component scores (PCS) and mental component scores (MCS) were calculated from SF-36 and normalized to the general population (mean ± SD = 50 ± 10) with lower scores indicating poorer HRQoL. The domains of Physical Function (PF), Role Physical (RP), Bodily Pain (BP), General Health perceptions (GH), Vitality (VT), Social Functioning (SF), Role Emotional (RE), Mental Health index (MH) were also evaluated. Results: The study included 304 patients; 220 (72%) women; mean age at diagnosis = 71.3±8.5 years; 58% enrolled within 12 weeks of diagnosis. Temporal artery biopsy was positive in 165/205 (81%) patients. Visual manifestations were present in 38%, upper extremity claudication in 18%, and lower extremity claudication in 6%. Disease was characterized as being in remission in 57% of patients. At least one damage item was present in 58%. Mean±SD PCS (39.7±11.5) and MCS (47.2±12.8) were statistically lower in patients with GCA compared to the general population, p < 0.01. PCS were lower in females (37.8 vs 43.3 in males, p < 0.01), patients with any damage item on VDI (38.0 vs 41.3 in patients with VDI=0, p 0.02) and patients with active disease (37.7 vs 41.3 in remission, p 0.01). Mean MCS was lower in patients with active disease (45.7 vs 48.8 in remission, p 0.04). There were no differences in PCS or MCS in patients with i) recently diagnosed disease, ii) with/without vision loss, iii) with/without upper or lower extremity claudication (p > 0.05). Domains of PF and BP were statistically lower in females, patients with damage had lower PF scores. Patients with active disease had lower RP, BP, VT, SF and MH scores Figure 1. SF-36 scores among patients with giant cell arteritis. Left panel: Differences in physical component score (PCS) and mental component score (MCS) in patients with active and inactive disease (solid line represents the general population). Right panel: Differences in domains of Physical Function (PF), Role Physical (RP), Bodily Pain (BP), General Health perceptions (GH), Vitality (VT), Social Functioning (SF), Role Emotional (RE), and Mental Health index (MH) in patients with giant cell arteritis based on presence or absence of active disease, and compared to the general population (GP). Conclusion: Patients with GCA have reduced HRQoL, as measured by the SF-36. While SF-36 appears sensitive to disease activity, it did not differ in patients with serious manifestations such as vision loss or limb claudication which would be expected to impact quality of life. Disease-specific measures may better capture the burden of disease from the patient’s perspective in GCA.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".