MP42-07 ONCOLOGICAL OUTCOMES OF PATIENTS WITH SPORADIC, NON-METASTATIC RENAL CELL CARCINOMA WITH RENAL VEIN OR INFERIOR VENA CAVA TUMOR THROMBUS
Notice bibliographique
Résumé
You have accessJournal of UrologyKidney Cancer: Localized: Surgical Therapy III (MP42)1 Apr 2019MP42-07 ONCOLOGICAL OUTCOMES OF PATIENTS WITH SPORADIC, NON-METASTATIC RENAL CELL CARCINOMA WITH RENAL VEIN OR INFERIOR VENA CAVA TUMOR THROMBUS Benjamin Shiff*, Rodney Breau, Alan So, Frederic Pouliot, Anil Kapoor, Jun Kawakami, Jean-Baptiste Lattouf, Ricardo Rendon, Simon Tanguay, Ranjeeta Mallick, and Rahul Bansal Benjamin Shiff*Benjamin Shiff* More articles by this author , Rodney BreauRodney Breau More articles by this author , Alan SoAlan So More articles by this author , Frederic PouliotFrederic Pouliot More articles by this author , Anil KapoorAnil Kapoor More articles by this author , Jun KawakamiJun Kawakami More articles by this author , Jean-Baptiste LattoufJean-Baptiste Lattouf More articles by this author , Ricardo RendonRicardo Rendon More articles by this author , Simon TanguaySimon Tanguay More articles by this author , Ranjeeta MallickRanjeeta Mallick More articles by this author , and Rahul BansalRahul Bansal More articles by this author View All Author Informationhttps://doi.org/10.1097/01.JU.0000556210.51056.a3AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVES: Tumor extension into the venous circulation is a well-described feature of renal cell carcinoma (RCC), and aggressive surgical management has been shown to provide cure in a substantial proportion of patients. However, the factors that contribute to variability in outcomes are poorly understood. This study was conducted to examine factors associated with survival in patients who had undergone surgery for non-metastatic RCC with venous tumor thrombus. METHODS: The Canadian Kidney Cancer information system (CKCis) database was used to identify a historical cohort of patients who underwent radical nephrectomy and removal of renal vein or inferior vena cava tumor thrombus for non-metastatic pathological T3 RCC from 2011 to 2018. Association of level of tumor thrombus was examined with recurrence-free survival (RFS) and overall survival (OS). Univariate and multivariate analyses were performed. RESULTS: Of the 165 patients identified from the database who satisfied the study criteria, 100, 37, and 28 patients had level 0-1, 2, and 3-4 thrombus, respectively . Mean age was 65 (standard deviation [SD] 10.9) years and 73% of patients were male. Median Charlson Comorbidity Index score was 3 (interquartile range [IQR] 2-4). Fuhrman tumor grade 4 was associated with poor RFS on univariate analysis (Hazard Ratio [HR] 0.47; 95% confidence interval [CI] 0.24-0.94; p-value 0.032), though this association only trended towards significance on multivariate analysis when adjusted for tumor size, margin status, and level of tumor thrombus (HR 0.51; 95% CI 0.24-1.09; p-value 0.081). The level of venous tumor thrombus did not impact the RFS or OS. Predicted 5-year survival rates were 63.7%, 68.3%, and 60.8% for tumor thrombus level 0-1, 2, and 3-4, respectively, with no significant difference between them (log-rank test p-value 0.25). Main limitations are retrospective design, selection bias and possible reporting bias. CONCLUSIONS: According to our data level of venous tumor thrombus is not associated with survival metrics in patients undergoing surgery for non-metastatic RCC with renal vein or inferior vena cava thrombus. Tumor grade may be associated with RFS in these patients. Source of Funding: None Winnipeg, Canada; Ottawa, Canada; Vancouver, Canada; Quebec City, Canada; Ontario, Canada; Calgary, Canada; Montreal, Canada; Halifax, Canada; Montreal, Canada; Ottawa, Canada; Winnipeg, Canada© 2019 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 201Issue Supplement 4April 2019Page: e608-e608 Advertisement Copyright & Permissions© 2019 by American Urological Association Education and Research, Inc.MetricsAuthor Information Benjamin Shiff* More articles by this author Rodney Breau More articles by this author Alan So More articles by this author Frederic Pouliot More articles by this author Anil Kapoor More articles by this author Jun Kawakami More articles by this author Jean-Baptiste Lattouf More articles by this author Ricardo Rendon More articles by this author Simon Tanguay More articles by this author Ranjeeta Mallick More articles by this author Rahul Bansal More articles by this author Expand All Advertisement PDF downloadLoading ...
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,005 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».