MP42-07 ONCOLOGICAL OUTCOMES OF PATIENTS WITH SPORADIC, NON-METASTATIC RENAL CELL CARCINOMA WITH RENAL VEIN OR INFERIOR VENA CAVA TUMOR THROMBUS
Bibliographic record
Abstract
You have accessJournal of UrologyKidney Cancer: Localized: Surgical Therapy III (MP42)1 Apr 2019MP42-07 ONCOLOGICAL OUTCOMES OF PATIENTS WITH SPORADIC, NON-METASTATIC RENAL CELL CARCINOMA WITH RENAL VEIN OR INFERIOR VENA CAVA TUMOR THROMBUS Benjamin Shiff*, Rodney Breau, Alan So, Frederic Pouliot, Anil Kapoor, Jun Kawakami, Jean-Baptiste Lattouf, Ricardo Rendon, Simon Tanguay, Ranjeeta Mallick, and Rahul Bansal Benjamin Shiff*Benjamin Shiff* More articles by this author , Rodney BreauRodney Breau More articles by this author , Alan SoAlan So More articles by this author , Frederic PouliotFrederic Pouliot More articles by this author , Anil KapoorAnil Kapoor More articles by this author , Jun KawakamiJun Kawakami More articles by this author , Jean-Baptiste LattoufJean-Baptiste Lattouf More articles by this author , Ricardo RendonRicardo Rendon More articles by this author , Simon TanguaySimon Tanguay More articles by this author , Ranjeeta MallickRanjeeta Mallick More articles by this author , and Rahul BansalRahul Bansal More articles by this author View All Author Informationhttps://doi.org/10.1097/01.JU.0000556210.51056.a3AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVES: Tumor extension into the venous circulation is a well-described feature of renal cell carcinoma (RCC), and aggressive surgical management has been shown to provide cure in a substantial proportion of patients. However, the factors that contribute to variability in outcomes are poorly understood. This study was conducted to examine factors associated with survival in patients who had undergone surgery for non-metastatic RCC with venous tumor thrombus. METHODS: The Canadian Kidney Cancer information system (CKCis) database was used to identify a historical cohort of patients who underwent radical nephrectomy and removal of renal vein or inferior vena cava tumor thrombus for non-metastatic pathological T3 RCC from 2011 to 2018. Association of level of tumor thrombus was examined with recurrence-free survival (RFS) and overall survival (OS). Univariate and multivariate analyses were performed. RESULTS: Of the 165 patients identified from the database who satisfied the study criteria, 100, 37, and 28 patients had level 0-1, 2, and 3-4 thrombus, respectively . Mean age was 65 (standard deviation [SD] 10.9) years and 73% of patients were male. Median Charlson Comorbidity Index score was 3 (interquartile range [IQR] 2-4). Fuhrman tumor grade 4 was associated with poor RFS on univariate analysis (Hazard Ratio [HR] 0.47; 95% confidence interval [CI] 0.24-0.94; p-value 0.032), though this association only trended towards significance on multivariate analysis when adjusted for tumor size, margin status, and level of tumor thrombus (HR 0.51; 95% CI 0.24-1.09; p-value 0.081). The level of venous tumor thrombus did not impact the RFS or OS. Predicted 5-year survival rates were 63.7%, 68.3%, and 60.8% for tumor thrombus level 0-1, 2, and 3-4, respectively, with no significant difference between them (log-rank test p-value 0.25). Main limitations are retrospective design, selection bias and possible reporting bias. CONCLUSIONS: According to our data level of venous tumor thrombus is not associated with survival metrics in patients undergoing surgery for non-metastatic RCC with renal vein or inferior vena cava thrombus. Tumor grade may be associated with RFS in these patients. Source of Funding: None Winnipeg, Canada; Ottawa, Canada; Vancouver, Canada; Quebec City, Canada; Ontario, Canada; Calgary, Canada; Montreal, Canada; Halifax, Canada; Montreal, Canada; Ottawa, Canada; Winnipeg, Canada© 2019 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 201Issue Supplement 4April 2019Page: e608-e608 Advertisement Copyright & Permissions© 2019 by American Urological Association Education and Research, Inc.MetricsAuthor Information Benjamin Shiff* More articles by this author Rodney Breau More articles by this author Alan So More articles by this author Frederic Pouliot More articles by this author Anil Kapoor More articles by this author Jun Kawakami More articles by this author Jean-Baptiste Lattouf More articles by this author Ricardo Rendon More articles by this author Simon Tanguay More articles by this author Ranjeeta Mallick More articles by this author Rahul Bansal More articles by this author Expand All Advertisement PDF downloadLoading ...
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".