PD36-06 THE EFFECT OF SELECTIVE BLADDER DENERVATION IN FEMALE REFRACTORY OVERACTIVE BLADDER WITH OR WITHOUT DETRUSOR OVERACTIVITY
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Résumé
You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Female Incontinence: Therapy III (PD36)1 Apr 2019PD36-06 THE EFFECT OF SELECTIVE BLADDER DENERVATION IN FEMALE REFRACTORY OVERACTIVE BLADDER WITH OR WITHOUT DETRUSOR OVERACTIVITY Raphaëlle Brière*, Patrick O. Richard, Matthieu Gratton, and Le Mai Tu Raphaëlle Brière*Raphaëlle Brière* More articles by this author , Patrick O. RichardPatrick O. Richard More articles by this author , Matthieu GrattonMatthieu Gratton More articles by this author , and Le Mai TuLe Mai Tu More articles by this author View All Author Informationhttps://doi.org/10.1097/01.JU.0000556350.93441.99AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVES: Selective bladder denervation (SBD) fulgurates, using radiofrequency (RF) energy, sub-trigonal tissue containing afferent nerves to interrupt afferent signaling thought to cause overactivity bladder (OAB) symptoms. We studied the efficacy of SBD in female patients with refractory OAB and compared clinical outcomes between those with and without detrusor overactivity (DO) as established on baseline urodynamic study (UDS). METHODS: This was a prospective observational study of 23 refractory OAB female patients who underwent SBD, using a 60-second temperature-controlled RF protocol, between May 2016 to April 2017. Patients were categorized according to DO status (DO- vs. DO+) on baseline UDS. Clinical outcomes were assessed at 12 weeks and 12 months for: 24h pad weight test (PWT), 3-day voiding diary parameters and subjective improvement assessed via OAB-q short form, Treatment Benefit Scale and subjective improvement rate. RESULTS: Both DO- and DO+ groups reported significant improvement from baseline at 12 weeks in the 24h PWT, urgency urinary incontinence (UUI)/3 days and urgency/3 days, and at 12 months in urgency/3 days. Individually, at 12 months, the 24h PWT decreased in the DO- group whereas UUI/3 days decreased in the DO+ group. When separating voids according to Patient Perception of Intensity of Urgency Scale (PPIUS), urgency-related voids/24h (grades 3 and 4) significantly decreased and non-urgency-related voids/24h (grades 0 to 2) increased in both groups at 12 weeks and in DO+ group at 12 months, which may suggest that overall voiding frequency is more driven by habit than urgency. Only PPIUS grade 3/24h decreased in the DO- group at 12 months. When directly comparing both group outcomes, the only significant difference was the greater reduction in UUI/3 days in the DO- group at 12 weeks (-9.0 vs. -6.5; p=0.045). DO- and DO+ groups were all subjectively improved at each follow-up (table 1). CONCLUSIONS: SBD appears to be an effective treatment, both objectively and subjectively, for refractory OAB female patients regardless of baseline DO status. These results need to be validated in a larger prospective randomized control trial. Source of Funding: Partial funding from Amphora Medical Inc. Quebec, Canada; Sherbrooke, Canada; Quebec, Canada; Sherbrooke, Canada© 2019 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 201Issue Supplement 4April 2019Page: e657-e657 Advertisement Copyright & Permissions© 2019 by American Urological Association Education and Research, Inc.MetricsAuthor Information Raphaëlle Brière* More articles by this author Patrick O. Richard More articles by this author Matthieu Gratton More articles by this author Le Mai Tu More articles by this author Expand All Advertisement PDF downloadLoading ...
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,001 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,020 | 0,002 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».