PD36-06 THE EFFECT OF SELECTIVE BLADDER DENERVATION IN FEMALE REFRACTORY OVERACTIVE BLADDER WITH OR WITHOUT DETRUSOR OVERACTIVITY
Bibliographic record
Abstract
You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Female Incontinence: Therapy III (PD36)1 Apr 2019PD36-06 THE EFFECT OF SELECTIVE BLADDER DENERVATION IN FEMALE REFRACTORY OVERACTIVE BLADDER WITH OR WITHOUT DETRUSOR OVERACTIVITY Raphaëlle Brière*, Patrick O. Richard, Matthieu Gratton, and Le Mai Tu Raphaëlle Brière*Raphaëlle Brière* More articles by this author , Patrick O. RichardPatrick O. Richard More articles by this author , Matthieu GrattonMatthieu Gratton More articles by this author , and Le Mai TuLe Mai Tu More articles by this author View All Author Informationhttps://doi.org/10.1097/01.JU.0000556350.93441.99AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVES: Selective bladder denervation (SBD) fulgurates, using radiofrequency (RF) energy, sub-trigonal tissue containing afferent nerves to interrupt afferent signaling thought to cause overactivity bladder (OAB) symptoms. We studied the efficacy of SBD in female patients with refractory OAB and compared clinical outcomes between those with and without detrusor overactivity (DO) as established on baseline urodynamic study (UDS). METHODS: This was a prospective observational study of 23 refractory OAB female patients who underwent SBD, using a 60-second temperature-controlled RF protocol, between May 2016 to April 2017. Patients were categorized according to DO status (DO- vs. DO+) on baseline UDS. Clinical outcomes were assessed at 12 weeks and 12 months for: 24h pad weight test (PWT), 3-day voiding diary parameters and subjective improvement assessed via OAB-q short form, Treatment Benefit Scale and subjective improvement rate. RESULTS: Both DO- and DO+ groups reported significant improvement from baseline at 12 weeks in the 24h PWT, urgency urinary incontinence (UUI)/3 days and urgency/3 days, and at 12 months in urgency/3 days. Individually, at 12 months, the 24h PWT decreased in the DO- group whereas UUI/3 days decreased in the DO+ group. When separating voids according to Patient Perception of Intensity of Urgency Scale (PPIUS), urgency-related voids/24h (grades 3 and 4) significantly decreased and non-urgency-related voids/24h (grades 0 to 2) increased in both groups at 12 weeks and in DO+ group at 12 months, which may suggest that overall voiding frequency is more driven by habit than urgency. Only PPIUS grade 3/24h decreased in the DO- group at 12 months. When directly comparing both group outcomes, the only significant difference was the greater reduction in UUI/3 days in the DO- group at 12 weeks (-9.0 vs. -6.5; p=0.045). DO- and DO+ groups were all subjectively improved at each follow-up (table 1). CONCLUSIONS: SBD appears to be an effective treatment, both objectively and subjectively, for refractory OAB female patients regardless of baseline DO status. These results need to be validated in a larger prospective randomized control trial. Source of Funding: Partial funding from Amphora Medical Inc. Quebec, Canada; Sherbrooke, Canada; Quebec, Canada; Sherbrooke, Canada© 2019 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 201Issue Supplement 4April 2019Page: e657-e657 Advertisement Copyright & Permissions© 2019 by American Urological Association Education and Research, Inc.MetricsAuthor Information Raphaëlle Brière* More articles by this author Patrick O. Richard More articles by this author Matthieu Gratton More articles by this author Le Mai Tu More articles by this author Expand All Advertisement PDF downloadLoading ...
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.020 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".