Notice bibliographique
Résumé
Background: Amino acid sequence homology between human thyroid autoantigens (human thyrotropin receptor, human thyroglobulin, human thyroperoxidase, human sodium iodide symporter) and Borrelia proteins has been reported (1). It has been suggested that Borrelia proteins may be capable of triggering autoimmune thyroid disease in persons with certain HLA-DR alleles (1). Clinical case: A 40-year-old male presented to the Emergency Department (ED) with 3 weeks of worsening night sweats, lethargy, and weakness. He previously had 5 oval shaped spots on his body which had appeared after a recent hiking trip but these had disappeared 1.5 weeks prior to his presentation. He had been experiencing positional chest pain for the 3 days prior to coming to the ED. On admission to the hospital he was found to be febrile and bradycardic with ECG revealing high-grade second-degree type II block. He was started on empiric antibiotics for suspected Lyme disease as he had been hiking in a Lyme endemic area. He also had thyroid indices sent off at the time of presentation which came back consistent with hyperthyroidism. The patient did not endorse neck pain or tenderness, visual symptoms, weight loss, diarrhea, tremors, or palpitations. Anti-TPO antibodies as well as a nuclear medicine thyroid uptake and scan were ordered. His anti-TPO antibodies were positive at 26 IU/mL (n<=6 IU/mL). His uptake at 5 hours of was 0.75%, which is markedly below the lower limit of normal (5%) and as such a thyroid scan could not be performed as there would have been insufficient counts to generate a diagnostic image. His hyperthyroidism was most in keeping with a thyroiditis. As such no thyroid specific treatment was initiated. His Lyme Western Blot IgG eventually returned positive. When he was seen in follow up in outpatient endocrinology clinic, thyroid indices revealed he was hypothyroid, in keeping with the hypothyroid phase often seen in thyroiditis. Conclusion: There are a few studies suggesting borrelia proteins may be capable of triggering autoimmune thyroid disease. This case is supportive of this theory and showcases a presentation of Lyme disease associated thyroiditis. References: (1) Benvenga, S., Guarneri, F. Molecular mimicry and autoimmune thyroid disease. Rev Endocr Metab Disord (2016) 17:485-498.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,001 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».